Cat. No. | Product Name | Target | Signaling Pathways |
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T21512 |
MMP-2/MMP-9 Inhibitor I
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MMP | Proteases/Proteasome |
MMP-2/MMP-9-IN-1 是一种有效的、具有高选择性和可口服的 IV 型胶原酶 (MMP-9和MMP-2) 抑制剂,对 MMP-9 和 MMP-2具有抑制作用, IC50分别为 0.24 和 0.3 1μM。MMP-2/MMP-9-IN-1 在肿瘤生长和转移的动物模型中展现出口服活性,可用于研究癌症。 | |||
T36962 |
MMP Inhibitor I (trifluoroacetate salt)
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MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urease, trypsin, α-chymotrypsin, plasmin, and elastase at concentrations up to 4 mM. | |||
T37726 |
MMP-9 Inhibitor I
|
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MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM. | |||
T37172 |
MMP-9/MMP-13 Inhibitor I
|
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MMP-9/MMP-13 Inhibitor I 是 MMP-9 和 MMP-13 双重抑制剂,IC50 均为 0.9 nM。MMP-9/MMP-13 Inhibitor I 对 MMP-9/MMP-13 的选择性是其他 MMP 的 20 倍以上。 | |||
T69666 |
MMP-8 Inhibitor I
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MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. | |||
T61491 |
(R)-ND-336
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(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1]. | |||
T79190 |
Homouridine
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Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Homouridine 是一种尿苷类似物,可作为中间体合成抑制剂 compound I(MMP-2 抑制剂, IC50=150 μM)。此外,Compound I (EP1338282) 也能抑制 TNF-α 与 TNF-αR1 的结合。 | |||
T62005 |
Imidapril
|
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Imidapril (TA-6366 free base) 是口服有效的血管紧张素转换酶(ACE)和MMP-9抑制剂。Imidapril 通过抑制血管紧张素 I 向血管紧张素 II 转化从而降低总外周阻力和血压。Imidapril 在高血压、1 型糖尿病、肾病和慢性心力衰竭中有研究价值。 | |||
T79476 | SCAL-255 | Mitochondrial Metabolism | Metabolism |
SCAL-255,作为有效的线粒体复合物 I (CI) 抑制剂,具有 1.14 μM 的 IC50 值。该化合物通过抑制 OCR、诱导 ROS 产生并降低 MMP,干扰线粒体功能,对氧化磷酸化(OXPHOS)依赖性癌细胞显示出显著的抗增殖活性。 | |||
T79477 | SCAL-266 | Mitochondrial Metabolism | Metabolism |
SCAL-266为线粒体复合物I (CI) 的有效抑制剂,IC50值为0.83 μM。它能够抑制线粒体功能,阻断氧耗量率(OCR),诱导活性氧(ROS)的产生,降低线粒体膜电位(MMP)。此外,SCAL-266对依赖氧化磷酸化(OXPHOS)的癌细胞展示出强烈的抗增殖效果。 | |||
T36844 |
Inostamycin A
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Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con... |