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Search Results for " mgl "

17

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3595	Resmetirom VIA-3196,MGL3196	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Resmetirom (VIA-3196) 是一种高度选择性的THR-β激动剂(EC50:0.21 μM)。
T7688	4-Nonylphenylboronic acid	FAAH	Metabolism; Neuroscience
	4-Nonylphenylboronic acid 是 FAAH 的抑制剂。
T12717	Basimglurant CTEP Derivative,RG7090	GluR	Neuroscience
	Basimglurant (CTEP Derivative) 是一种高效，选择性，可口服的 mGlu5负变构调节剂，Kd 值为1.1 nM。
T9970	mGluR3 modulator-1 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈	GluR	Neuroscience
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) 是 mGluR3 的正变构调节剂，可用于治疗帕金森病的研究。
T74287	MGlc-DAG
	MGlc-DAG 是一种糖脂甘油酯，可用于合成药物递送化合物。
T61775	mGlu4 receptor agonist 1
	mGlu4 receptor agonist 1 (compound 62) is a highly effective positive allosteric modulator of mGlu4 receptors, displaying an EC 50 of 308 nM. Additionally, it exhibits noteworthy anxiolytic and antipsychotic properties [1].
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T81801	mGluR5 antagonist-1
	mGluR5 antagonist-1，一种高亲和力的mGluR5拮抗剂，其IC50为11.5 nM，表现出抗抑郁活性。
T38910	mGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies.
T60882	mGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) 可用于抗精神病药物研究。mGluR2 modulator 2 是一种有效的、选择性和口服生物可利用的mGluR2正变构调节剂，EC50值为 0.13 μM。
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) 是一种有效的、具有血脑屏障通透性的 mGluR2 (代谢型谷氨酸受体-2)正向变构调节剂 (EC50: 0.03 μM)。mGluR2 modulator 1 能够用于研究精神病。
T38659	mGluR5 modulator 1
	mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment research.
T3591	URB602	Lipase; Antibacterial	Metabolism; Microbiology/Virology
	URB602 是选择性单酰基甘油脂肪酶 (MGL) 抑制剂，非竞争性抑制大鼠脑 MGL，IC50为 28±4 μM。
T28165	NF-1819 NF 1819,NF1819	Lipase	Metabolism
	NF-1819 是一种高效、选择性的不可逆 MGL (β-内酰胺基单酰甘油脂肪酶)抑制剂。NF-1819 在体内多发性硬化症模型中缓解疾病症状，在体内急性炎性疼痛模型中表现出镇痛作用。NF-1819 具有较高的膜通透性和血脑屏障通透性。
T34521	SAR629 SAR 629,SAR-629
	SAR-629 is an MGL inhibitor or 2-AG degradation inhibitor.
T71493	AM6580
	AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor.
T61294	Monoacylglycerol lipase inhibitor 1
	Monoacylglycerol lipase inhibitor 1 是一种有效的单酰基甘油脂肪酶 (MGL) 抑制剂 (化合物 13)。

化合物

Cat.No: T3595

Synonym: VIA-3196,MGL3196

Target: Thyroid hormone receptor(THR)

4-Nonylphenylboronic acid

Cat.No: T7688

Target: FAAH

Cat.No: T12717

Synonym: CTEP Derivative,RG7090

Target: GluR

mGluR3 modulator-1

Cat.No: T9970

Synonym: 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈

Target: GluR

Cat.No: T74287

mGlu4 receptor agonist 1

Cat.No: T61775

mGluR2 modulator 4

Cat.No: T61277

mGluR5 antagonist-1

Cat.No: T81801

mGluR2 antagonist 1

Cat.No: T38910

mGluR2 modulator 2

Cat.No: T60882

mGluR2 modulator 1

Cat.No: T62202

mGluR5 modulator 1

Cat.No: T38659

Cat.No: T3591

Target: Lipase, Antibacterial

Cat.No: T28165

Synonym: NF 1819,NF1819

Target: Lipase

Cat.No: T34521

Synonym: SAR 629,SAR-629

Cat.No: T71493

Monoacylglycerol lipase inhibitor 1

Cat.No: T61294

Cat. No.	Product Name	Target	Signaling Pathways
T5737	euphol	Others; Lipase; Endogenous Metabolite	Metabolism; Others
	Euphol 是从Euphorbia tirucalli 的汁液中分离出来的四环三萜醇，具有抗炎和免疫调节作用，口服具有活力。它通过能够逆机制抑制单酰基甘油脂肪酶 (MGL) 的特性，IC50=315 nM。外周 MGL 抑制能够调节内源性大麻素系统从而阻止炎症性疼痛的发展。
T4S1050	Pristimerin 扁塑藤素,Celastrol methyl ester	NF-κB; Antibacterial	Microbiology/Virology; NF-κB
	Pristimerin (Celastrol methyl ester) 是一种可逆的单酰基甘油脂肪酶高效抑制剂，IC50值为93 nM。

天然产物

Cat.No: T5737

Target: Others, Lipase, Endogenous Metabolite

Cat.No: T4S1050

Synonym: 扁塑藤素,Celastrol methyl ester

Target: NF-κB, Antibacterial

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