4
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36680 |
SM1-71
|
Serine/threonin kinase; MAPK; LIM Kinase; TGF-beta/Smad; AAK1 (AP2 associated kinase 1) | Cell Cycle/Checkpoint; MAPK; Metabolism; Neuroscience; Stem Cells |
SM1-71 是一种有效的多靶点丙烯酰胺修饰的 TAK1 抑制剂,抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 可作为激酶探针,具有抗癌活性,抑制多种癌细胞系的增殖。 | |||
T27416 |
GLPG0259
GLPG-0259,GLPG 0259 |
||
GLPG-0259 is an inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5). | |||
T83740 |
Ziptide TFA
|
||
Ziptide是多种丝氨酸/苏氨酸蛋白激酶的肽底物,包括MAPK激活蛋白激酶2(MAPKAPK2)、MAPKAPK3、MAPKAPK5、checkpoint kinase 1(Chk1)、AMP激活蛋白激酶(AMPK)和钙/钙调蛋白依赖型蛋白激酶II(CamKII)。它被用来评估CamKII活性以用于抑制剂的开发。 | |||
T71274 |
GLPG0259 A
|
||
GLPG0259 A is a small-molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), a kinase enzyme that plays a role in important inflammatory pathways. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00696 |
PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)
MAPKAPK5,MK5,MAPKAP-K5,M... |
Human | Baculovirus Insect Cells |
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-activated protein kinase activated protein kinase 5 [MAPKAPK5]) functions downstream of p38alpha and p38beta in mediating the signaling of the p38 pathway. | |||
TMPY-04425 |
PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)
PRAK,MAPKAP-K5,MK-5,mitogen-activated prot... |
Human | Baculovirus Insect Cells |
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulator... | |||
TMPY-04260 |
p38 Protein, Human, Recombinant (His)
mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB... |
Human | Baculovirus Insect Cells |
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ... | |||
TMPH-01692 |
MAPK3 Protein, Human, Recombinant (His)
|
Human | E. coli |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c... |