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抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T60810	Influenza virus-IN-2
	Influenza virus-IN-2 (compound 19) 具有抗甲型流感病毒活性，是有效的流感病毒抑制剂，CC50值为 150.85 μM，EC50值为 2.58 μM,。Influenza virus-IN-2 浓度依赖性的抑制 PAN 核酸内切酶，EC50为 489.39 nM。
T38236	2′-Deoxy-2′-fluoroguanosine	Nucleoside Antimetabolite/Analog; Influenza Virus	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	2′-Deoxy-2′-fluoroguanosine 是一种核苷类似物，有效抑制流感病毒，抑制A 型和B 型流感病毒的EC90值 <0.35 μM。2′-Deoxy-2′-fluoroguanosine 显著抑制流感病毒在上呼吸道中的复制，从而改善鼻腔炎症和发烧。
T60951	Molnupiravir EIDD-2801,Lagevrio,MK-4482	SARS-CoV; Influenza Virus	Microbiology/Virology
	Molnupiravir (MK-4482) (EIDD-2801) 是核糖核苷类似物 EIDD-1931 的异丙酯前体药物，具有口服生物利用度。Molnupiravir 可用于 COVID-19 ，季节性和流行性流感的研究，对多种冠状病毒和流感病毒具有广谱的抗病毒活性，例如，SARS-CoV-2，MERS-CoV，SARS-CoV。
T64297	Triton X-100
	Triton X-100 是一种溶解脂膜的非变性洗涤剂。Triton X-100 通常用于实验室，并在生产过程的不同阶段应用于疫苗。Triton X-100 被列为某些疫苗,包括裂解病毒流感疫苗的赋形剂。Triton X-100 是一种非离子表面活性剂。
TP1867	PA (224-233), Influenza
	PA (224-233), Influenza is a 10-aa peptide, which is a fragment of polymerase 2 protein in Influenza a virus.
T39292	NS2 (114-121), Influenza NS2 (114-121), Influenza
	NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses.
T10677	Carbodine	Others	Others
	Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent and targets CTP synthetase that converts UTP to CTP. It possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro.
T60910	RSV-IN-4
	RSV-IN-4 (Compound 2) 具有抗 RSV 活性，EC50值为11.76 μM。RSV-IN-4 是呼吸道合胞病毒 (RSV) 和甲流病毒 A (IAV) 的双重抑制剂。
T27038	CL385319 HCl CL-385319,CL385319 hydrochloride,CL 385319,CL385319
	CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.
T60970	Caprochlorone
	Caprochlorone 对正痘病毒具有抗病毒活性，可以降低被感染的小鼠肺部中流感病毒的滴度。Caprochlorone 可以抑制病毒穿透细胞，并且延迟新形成的病毒从细胞释放。
T7911	Arbidol
	Umifenovir 是一种有效的口服活性广谱抗病毒药物，对许多包膜病毒和非包膜病毒具有活性。Umifenovir 既能抑制病毒繁殖又能调节炎性细胞因子的表达，可用作抗流感病毒剂 (anti-influenza virus)，并具有抗炎活性。Umifenovir 有效抑制病毒与宿主细胞的融合。 Umifenovir 是体外有效的 SARS-CoV-2的抑制剂。
T64177	Cap-dependent endonuclease-IN-2
	Cap-dependent endonuclease-IN-2 是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-2 对流感病毒具有很好的抑制作用，且细胞毒性较低，具有较好的体内药剂动力学特性和体内药效学特性。Cap-dependent endonuclease-IN-2 能够明显的抑制甲型流感病毒 RNA 聚合酶活性。
T73336	Ketotifen 酮替芬,HC 20-511
	Ketotifen (HC 20-511)为第二代口服活性非竞争性组胺1(H1)受体阻滞剂兼肥大细胞稳定剂，能体外阻断6-磷酸葡萄糖酸脱氢酶(6-PGD)。其对SARS-CoV-2及流感病毒(Influenza virus)展现出抗病毒活性，适用于自身免疫性脑脊髓炎(EAE)与哮喘发作预防研究。
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC90值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...
T38008	KBC-007
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at a concentration of 8 ng/ml. KBC-007 (1 μg per animal) increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum. KBC-007 (0.5 μg per animal) increases the sur...
T36986	Colletodiol
	Colletodiol is a fungal metabolite that has been found inD. grovesiiand has immunosuppressant and antiviral activities.1,2It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 μg/ml, respectively).1Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.2 1.Fujimoto, H., Nagano, J., Yamaguchi, K., et al.Immunosuppressive components from an ascomycete, Diplogelasinospora grovesiChem. Pharm. Bull.46(3)423-429(1998) 2.Lai, W., Wang...
T75291	Trimethoprim hydrochloride
	Trimethoprim hydrochloride 是一种口服活性的抑菌抗生素，同时也是二氢叶酸还原酶抑制剂。它对多种革兰氏阳性及革兰氏阴性需氧细菌有效。用于尿路感染、志贺氏菌病和肺孢子菌肺炎的研究。与锌联合使用时，可抑制甲型流感病毒对鸡胚的感染。
T37843	Australine (hydrochloride)
	Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehal...

化合物

Influenza virus-IN-2

Cat.No: T60810

2′-Deoxy-2′-fluoroguanosine

Cat.No: T38236

Target: Nucleoside Antimetabolite/Analog, Influenza Virus

Cat.No: T60951

Synonym: EIDD-2801,Lagevrio,MK-4482

Target: SARS-CoV, Influenza Virus

Cat.No: T64297

PA (224-233), Influenza

Cat.No: TP1867

NS2 (114-121), Influenza

Cat.No: T39292

Synonym: NS2 (114-121), Influenza

Cat.No: T10677

Target: Others

Cat.No: T60910

Cat.No: T27038

Synonym: CL-385319,CL385319 hydrochloride,CL 385319,CL385319

Cat.No: T60970

Cat.No: T7911

Cap-dependent endonuclease-IN-2

Cat.No: T64177

Cat.No: T73336

Synonym: 酮替芬,HC 20-511

Viral polymerase-IN-1 hydrochloride

Cat.No: T74765

Cat.No: T38297

Synonym: Ribavirin-13C5

Cat.No: T38008

Cat.No: T36986

Trimethoprim hydrochloride

Cat.No: T75291

Australine (hydrochloride)

Cat.No: T37843

Cat. No.	Product Name	Target	Signaling Pathways
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。

天然产物

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

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