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Search Results for " il-33 "

Targets Recommended: Interleukin

9

抑制剂 & 化合物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76910	Astegolimab RG 6149,MSTT 1041A	Interleukin	Immunology/Inflammation
	Astegolimab (RG 6149) 是一种人源化靶向 IL-33 受体的 IgG2 单克隆抗体，可抑制 IL-33 信号传导。Astegolimab 可用于研究慢性阻塞性肺疾病 (COPD) 和成人严重哮喘。
T77045	Itepekimab REGN-3500,SAR-440340	Others	Others
	Itepekimab (REGN-3500) 是一种有效的抗 IL-33 的单克隆抗体。Itepekimab 在体内实验中可减少气道炎症和相关组织损伤，可用来研究哮喘疾病。
T76679	Etokimab
	Etokimab（Antibody ANB 020），一种人源化单克隆抗体，靶向IL-33，主要用于特应性皮炎的研究。
T83741	S7 TFA Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
	S7是一种IL-6受体的肽类拮抗剂，能够浓度依赖性地抑制IL-6与IL-6受体的结合。在C-33 A宫颈癌细胞和RPMI-8226 B细胞淋巴细胞中，S7 (50 µM) 能抑制IL-6诱导的VEGF水平增加。在每两天给药一次，剂量为50 mg/kg的条件下，S7能减少IL-6过表达的C-33 A宫颈癌小鼠异种移植模型中的肿瘤体积。当S7与半胱氨酸结合，并连接到包裹多柔比星的脂质纳米粒子(LNPs)表面时，能增强LNPs对胶质瘤的靶向性，并在U251胶质母细胞瘤小鼠异种移植模型中提高生存率。
T73149	HPK1-IN-33
	HPK1-IN-33（化合物21）是造血祖细胞激酶1（HPK1）的高效抑制剂，其Ki值为1.7 µM。此化合物在Jurkat WT细胞中抑制IL-2产生的EC50为286 nM，而在Jurkat HPK1 KO细胞中的EC50则大于10000 nM。
T29542	AC708 AC 708,AC-708
	AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells cultured in CSF-1 (IC50 = 38 nM) or IL-34
T69671	SR1903 TFA
	SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-190...
T35638	SR 1903
	SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 209 nM) but does not activate it. SR 1903 (10 μM) inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) in RAW 264.7 cells. It also inhibits LPS-induced expression of th...
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...

化合物

Cat.No: T76910

Synonym: RG 6149,MSTT 1041A

Target: Interleukin

Cat.No: T77045

Synonym: REGN-3500,SAR-440340

Target: Others

Cat.No: T76679

Cat.No: T83741

Synonym: Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH

Cat.No: T73149

Cat.No: T29542

Synonym: AC 708,AC-708

Cat.No: T69671

Cat.No: T35638

Cat.No: T37052

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01210	IL-33 Protein, Mouse, Recombinant Interleukin-1 family member 11,白细胞介素,NF-HEV and	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ...
TMPJ-00617	IL-33 Protein, Rhesus macaque, Recombinant (His) Interleukin-33,IL1F11,IL33	Rhesus	E. coli
	Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways...
TMPY-02789	IL-33 Protein, Canine, Recombinant 白介素,interleukin 33,白细胞介素	Canine	E. coli
	IL-33 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.8 kDa and the accession number is O97863.
TMPY-05449	IL-33 Protein, Cynomolgus, Recombinant 白细胞介素,interleukin 33,白介素	Cynomolgus	E. coli
	IL-33 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.1 kDa and the accession number is A0A2K5W3I1.
TMPY-00861	IL-33 Protein, Human, Recombinant IL1F11,C9orf26,NFEHEV,NF-HEV,DVS27,白介素,interleukin ...	Human	E. coli
	IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1.
TMPK-00163	IL-33 Protein, Cynomolgus, Recombinant (His) IL1F11,C9orf26 Z,C9ORF26,DV27,RP11-575C20.2,NFEHEV,...	Cynomolgus	HEK293 Cells
	Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
TMPH-03115	IL-33 Protein, Pig, Recombinant (GST)	Sus scrofa (Pig)	E. coli
	N/A. IL-33 Protein, Pig, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 44.6 kDa and the accession number is M5B263.
TMPK-00405	IL-17RA Protein, Human, Recombinant (aa 33-320, hFc & Avi), Biotinylated IL-7R-alpha,IL-7R,ILRA,IL	Human	HEK293 Cells
	Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22.
TMPK-01029	IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His) C3orf13,IL1RAP,IL-1 R3,IL-1 RAcP	Mouse	HEK293 Cells
	Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.
TMPK-01202	CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated C1QR1,C1q/MBL/SPA receptor,ECSM3,C1qRp,C1qR(p),C1qR,dJ737E23...	Human	HEK293 Cells
	CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperresponsiveness and inflammation with Th2 cytokine activation, along with decreased CD93 expression in bronchial epithelial cells and lung homogenates but increased serum CD93 levels.
TMPJ-01361	Siglec-8 Protein, Human, Recombinant (mFc) CD329 antigen,Siglec-8,SAF2SAF-2,CDw329,Siglec8,SAF-2,SAF2	Human	HEK293 Cells
	Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 c...

重组蛋白

IL-33 Protein, Mouse, Recombinant

Cat.No: TMPJ-01210

Species: Mouse

Expression System: E. coli

IL-33 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00617

Species: Rhesus

Expression System: E. coli

IL-33 Protein, Canine, Recombinant

Cat.No: TMPY-02789

Species: Canine

Expression System: E. coli

IL-33 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-05449

Species: Cynomolgus

Expression System: E. coli

IL-33 Protein, Human, Recombinant

Cat.No: TMPY-00861

Species: Human

Expression System: E. coli

IL-33 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00163

Species: Cynomolgus

Expression System: HEK293 Cells

IL-33 Protein, Pig, Recombinant (GST)

Cat.No: TMPH-03115

Species: Sus scrofa (Pig)

Expression System: E. coli

IL-17RA Protein, Human, Recombinant (aa 33-320, hFc & Avi), Biotinylated

Cat.No: TMPK-00405

Species: Human

Expression System: HEK293 Cells

IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)

Cat.No: TMPK-01029

Species: Mouse

Expression System: HEK293 Cells

CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated

Cat.No: TMPK-01202

Species: Human

Expression System: HEK293 Cells

Siglec-8 Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-01361

Species: Human

Expression System: HEK293 Cells

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