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Search Results for " igf-ii "

Targets Recommended: Apoptosis IGF-1R

3

抑制剂 & 化合物

2

化合物库

15

重组蛋白

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Cat. No.	Product Name
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L1600	激酶抑制剂库		2720 compounds
	2720 种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；

化合物库

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

激酶抑制剂库

Cat.No: L1600

Compounds: 2720

Cat. No.	Product Name	Target	Signaling Pathways
T2085	PQ401 IGF-1R Inhibitor II	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	PQ401 (IGF-1R Inhibitor II) 是一种IGF-IR 抑制剂。在 MCF-7 细胞中，它抑制 IGF-I 刺激的 IGF-IR 自磷酸化，可有效抑制 IGF-I 刺激的 MCF-7 细胞生长。它诱导 caspase 介导的细胞凋亡，有用于乳腺癌和其他对 IGF-I 敏感的癌症的研究潜力。
T76539	Insulin-like growth factor II
	Insulin-like growth factor II (IGF-2)为人血清中主要生长激素，对神经突生长具有许可性和直接作用，同时增强交感与感觉神经元的生存能力。
T81406	Preptin (rat)
	Preptin 在剂量依赖的方式下刺激胎鼠原代成骨细胞和成骨样细胞系的增殖，影响表现在细胞数量和DNA合成上。

化合物

Cat.No: T2085

Synonym: IGF-1R Inhibitor II

Target: Apoptosis, IGF-1R

Insulin-like growth factor II

Cat.No: T76539

Cat.No: T81406

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00061	IGF2/IGF-II Protein, Human, Recombinant (hFc) IGF2,IGF-II,PP1446,Somatomedin A,...	Human	HEK293 Cells
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in cell proliferation, apoptosis, protein synthesis and metabolism due to their homologous sequences and structural similarities. Insulin-like growth factor 2, a member of the insulin family, plays an important role in embryonic development, metabolic disorders, and tumorigenesis by ...
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-li...	Human	P. pastoris (Yeast)
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br...
TMPK-01354	IGF2R Protein, Human, Recombinant (His & Avi) M6P/IGF2R,IGF-II receptor,MPRI,CI...	Human	HEK293 Cells
	The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. IGF2R Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 164.90 kDa and the accession number is P11717.
TMPK-01361	IGF2R Protein, Human, Recombinant (His & Avi), Biotinylated MPR 300,IGF-II receptor,M6PR,M6P/IGF	Human	HEK293 Cells
	The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. IGF2R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 164.90 kDa and the accession number is P11717.
TMPK-01353	IGF2R Domain 1-3 Protein, Human, Recombinant (His & Avi) CI-MPR,MPR 300,MPRI,M6P/IGF2R,M6PR,CD222,IGF	Human	HEK293 Cells
	The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. IGF2R Domain 1-3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.50 kDa and the accession number is P11717.
TMPK-01355	IGF2R Domain 1-7 Protein, Human, Recombinant (His & Avi) IGF-II receptor,CI-MPR,CD222,M6P/IGF	Human	HEK293 Cells
	The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. IGF2R Domain 1-7 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 117.40 kDa and the accession number is P11717.
TMPH-00274	IGF2/IGF-II Protein, Bovine, Recombinant (hFc)	Bovine	P. pastoris (Yeast)
	IGF2/IGF-II Protein, Bovine, Recombinant (hFc) is expressed in yeast with N-hFc tag. The predicted molecular weight is 34.1 kDa and the accession number is P07456.
TMPH-02727	IGF2/IGF-II Protein, Mouse, Recombinant (His)	Mouse	E. coli
	IGF2/IGF-II Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.4 kDa and the accession number is P09535.
TMPJ-00345	IGF2BP-2 Protein, Human, Recombinant (His) IGF-II mRNA-Binding Protein 2,IGF...	Human	E. coli
	Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replicat...
TMPJ-00781	LR3-IGF-1 Protein, Mouse, Recombinant (His) IGF1,insulin-like growth factor 1,Insulin-like grow...	Mouse	E. coli
	Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IG...
TMPK-01371	IGFBP-7 Protein, Human, Recombinant (hFc) RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC25,IGFBP-...	Human	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres...
TMPK-01027	IGFBP-7 Protein, Mouse, Recombinant (hFc) TAF,RAMSVPS,IBP7,PSF,IGFBP-7,MAC25,IGFBPRP...	Mouse	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Mouse, Recombinant (hFc) is expres...
TMPY-00471	INSL4 Protein, Human, Recombinant (His) EPIL,insulin-like 4 (placenta),PLACENTIN	Human	HEK293 Cells
	INSL4 (Insulin-Like 4) is a Protein Coding gene. An important paralog of this gene is RLN1. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains or just the A and B chains. INSL4 is a member of the insulin family, which includes insulin, IGF-I, IGF-II, relaxin, and INSL3.INSL4 distribution was tissue- and cell-specific. Indeed, INSL4 mRNA was most abundant in syncytiotrophoblas...
TMPY-00894	PAPP-A2 Protein, Human, Recombinant (His) pappalysin 2,PAPP-E,PLAC3,PAPPE,PAPP-A2	Human	HEK293 Cells
	Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member. There is no homology between the prepro-peptides of PAPP-A and PAPP-A2, but 46% of the residues of mature PAPP-A are also present in mature PAPP-A2. PAPP-A specifically cleaves insulin-like growth factor-binding protein(IGFBP)-4, one of six known modulators of IGF-I and –II, whereas PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In cont...
TMPY-01762	IGF2BP-2 Protein, Human, Recombinant (His & GST) insulin-like growth factor 2 mRNA binding protein 2,IMP-2,VI...	Human	Baculovirus Insect Cells
	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the IGF-II mRNA-binding protein (IMP) family. IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to bind to several different mRNAs in mammalian cells, including one of the mRNAs encoding insulin-like growth factor-2. Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is involved in the stimulation of insulin action. IGF2BP2 / IMP2 is expressed in oocytes, granulosa c...

重组蛋白

IGF2/IGF-II Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00061

Species: Human

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Human, Recombinant

Cat.No: TMPY-00150

Species: Human

Expression System: P. pastoris (Yeast)

IGF2R Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01354

Species: Human

Expression System: HEK293 Cells

IGF2R Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01361

Species: Human

Expression System: HEK293 Cells

IGF2R Domain 1-3 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01353

Species: Human

Expression System: HEK293 Cells

IGF2R Domain 1-7 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01355

Species: Human

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Bovine, Recombinant (hFc)

Cat.No: TMPH-00274

Species: Bovine

Expression System: P. pastoris (Yeast)

IGF2/IGF-II Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02727

Species: Mouse

Expression System: E. coli

IGF2BP-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00345

Species: Human

Expression System: E. coli

LR3-IGF-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00781

Species: Mouse

Expression System: E. coli

IGFBP-7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01371

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01027

Species: Mouse

Expression System: HEK293 Cells

INSL4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00471

Species: Human

Expression System: HEK293 Cells

PAPP-A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00894

Species: Human

Expression System: HEK293 Cells

IGF2BP-2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01762

Species: Human

Expression System: Baculovirus Insect Cells

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