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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8721L |
I-37 free base( 2359690-13-2(free base))
|
Raf | MAPK |
I-37 free base( 2359690-13-2(free base)) 是一种新型苄氨基取代的吡啶并嘧啶酮,可作为 SOS1 抑制剂。 | |||
T8721 |
I-37
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]- |
Raf | MAPK |
I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) 是一种新型苄氨基取代的吡啶并嘧啶酮,可作为 SOS1 抑制剂。 | |||
T67748 |
ROCK-IN-5
|
ROCK; ERK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Stem Cells |
ROCK-IN-5(化合物I-B-37)是一种有效的蛋白激酶抑制剂,包括ROCK、ERK、GSK 和AGC。ROCK-IN-5在心脏病、增殖性疾病和神经退行性疾病研究方面具有潜力。 | |||
TP1730L |
β-catenin peptide acetate(265669-37-2 free base)
|
Others | Others |
β-catenin peptide acetate(265669-37-2 free base) 是一种由 Kb 呈递的天然存在的自身肽,可非常有效地介导 OT-I 胸腺细胞的阳性选择。 | |||
T81373 |
Proteasome β2c/i-IN-1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Proteasomeβ2c/i-IN-1(compound 37)为针对β2c和β2i亚基的选择性蛋白酶抑制剂。 | |||
T125185 | Kudinoside I | ||
Kudinoside I 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125185,CAS号为 258343-37-2。 | |||
T79355 |
PRMT4-IN-3
|
Histone Methyltransferase | Chromatin/Epigenetic |
PRMT4-IN-3 (compound 56) 作为一种针对 I 类蛋白质精氨酸甲基转移酶 (PRMT) 的抑制剂,对 PRMT4 具有高效抑制作用,表现出对PRMT4(IC50: 37 nM) 和PRMT6(IC50: 253 nM) 的选择性。 | |||
TP1971 |
Pseudo RACK1
|
||
Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide i | |||
T38101 |
Bisucaberin
|
||
Bisucaberin is a siderophore and bacterial metabolite that has been found inA. haloplanktisand has anticancer activity.1,2It inhibits the growth of L1210 and 1MC carcinoma cells (IC50s = 9.7 and 12.7 μM, respectively) and sensitizes fibrosarcoma 1023 cells to macrophage-mediated cytolysis. 1.Hou, Z., Raymond, K.N., O’Sullivan, B., et al.A preorganized siderophore: Thermodynamic and structural characterization of alcaligin and bisucaberin, microbial macrocyclic dihydroxamate chelating agentsInorg... | |||
T35814 |
Urocortin III (human) (trifluoroacetate salt)
|
||
Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively).... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36417 |
Nargenicin
Antibiotic 47444 |
||
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (... |