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Search Results for " ht-1080 "

14

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8922	SRS11-92 AA9	Ferroptosis	Apoptosis
	SRS11-92 (AA9) 是一种铁死亡抑制剂和 Ferrostatin-1 的衍生物。它抑制 Erastin 诱导的 HT-1080 人纤维肉瘤细胞铁致细胞死亡，EC50为6 nM。
T8317	5'-Fluoroindirubinoxime 5'-FIO	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	5'-Fluoroindirubinoxime (5'-FIO) 是一种 Indirubin 的衍生物，是一种 FLT3 的抑制剂(IC50:15 nM)。
T6500	Ferrostatin-1 Ferrostatin 1,Ferrostatin-1 (Fer-1)	Ferroptosis; Antifungal	Apoptosis; Microbiology/Virology
	Ferrostatin-1 (Fer-1) 是一种铁死亡抑制剂，具有强效性和选择性。Ferrostatin-1 有效抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 还具抗氧化和抗真菌活性。
T4309	CIL56 CA3	Ferroptosis; ROS	Apoptosis; Immunology/Inflammation
	CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。
T6334	Ridaforolimus AP23573,Deforolimus,MK-8669	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。
T36404	PRLX-93936
	PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM...
T70527	DAT-230
	DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated ...
T36398	Paclitaxel octadecanedioate
	Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft mo...
T32009	GSK321 GSK 321,GSK-321
	GSK321 is an effective and selective IDH1 mutation inhibitor, which can effectively inhibit the production of 2-HG in HT-1080 cells, and induce IDH1 mutant cells to differentiate into bone marrow at the level of leukemia blasts and more stem cells.
T35994	Erastin2 Erastin2
	Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 &#181M).[2] It induces cell death in HAP1 cells when used at a concentration of 5 &#181M, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 &#181M), an effect that can be blocked by the reducing agent β-merc...
T82408	Ferroptosis-IN-3	Ferroptosis	Apoptosis
	Ferroptosis-IN-3（Compound 25）是一款抑制RSL3引起的铁死亡（HT-1080细胞中EC50为8.6nM）的铁死亡抑制剂。此外，Ferroptosis-IN-3能有效清除DPPH和ABTS自由基（EC50分别为3.94μM与6.3μM），并且能降低脂质过氧化水平。
T82767	CC-3060
	CC-3060为Cereblon调节剂，专门促进ZBTB16蛋白的降解。在HT-1080细胞中，CC-3060的ZBTB16降解半数有效浓度（DC50）为0.47 nM。其主要机制是通过针对ZBTB16上的不同锌指结构域的异构结构实现靶向降解。
T83780	GPX4 24 Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
	GPX4 24是(1S,3R)-RSL3的衍生物，具有抑制谷胱甘肽过氧化物酶4（GPX4）的作用。它能够在浓度依赖的方式中与4T1小鼠乳腺癌细胞中的GPX4形成共价结合。在GPX4依赖的HT-1080成纤维细胞中，GPX4 24诱导铁死亡（EC50 = 0.16 µM）。当以200 mg/kg剂量给予小鼠时，它能够增加小鼠肾脏和血浆中丙二醛（MDA）的水平。
T83886	icFSP1 TFA
	icFSP1是一种抑制剂，针对的是铁死亡抑制蛋白1（FSP1）。在2.5 µM的浓度下使用时，能够引发FSP1在细胞中的凝聚和相分离，但在无细胞测试中并不抑制FSP1的酶活性（IC50 = > 30 µM）。icFSP1以浓度依赖的方式诱导HT-1080纤维肉瘤细胞的铁死亡。在体内，icFSP1（50 mg/kg）通过使用人类过表达FSP1，Gpx4-/-Fsp1-/-的B16/F10细胞，在B16/F10鼠黑色素瘤模型中减少肿瘤体积和重量。

化合物

Cat.No: T8922

Synonym: AA9

Target: Ferroptosis

5'-Fluoroindirubinoxime

Cat.No: T8317

Synonym: 5'-FIO

Target: FLT

Cat.No: T6500

Synonym: Ferrostatin 1,Ferrostatin-1 (Fer-1)

Target: Ferroptosis, Antifungal

Cat.No: T4309

Synonym: CA3

Target: Ferroptosis, ROS

Cat.No: T6334

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

Cat.No: T36404

Cat.No: T70527

Paclitaxel octadecanedioate

Cat.No: T36398

Cat.No: T32009

Synonym: GSK 321,GSK-321

Cat.No: T35994

Synonym: Erastin2

Ferroptosis-IN-3

Cat.No: T82408

Target: Ferroptosis

Cat.No: T82767

Cat.No: T83780

Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

Cat.No: T83886

Cat. No.	Product Name	Target	Signaling Pathways
T64343	3-Methylcarbazole NSC 10154	Others	Others
	3-Methylcarbazole (NSC-10154) 是具有抗癌作用的咔唑生物碱化合物。3-Methylcarbazole 对人纤维肉瘤 HT-1080 细胞具有生长抑制活性 (IC50 为 25 μg/mL)。
TN3854	Dihydroniloticin	Others	Others
	Dihydroniloticin shows cytotoxic activity against a HT-1080 human fibrosarcoma cell line( IC50 = 8.2 microM).
TN3307	9,10-Dimethoxycanthin-6-one	Others	Others
	9,10-Dimethoxycanthin-6-one shows cytotoxic activity against a HT-1080 human fibrosarcoma cell line( IC50 = 5.0 microM).
TN3571	Calyxin B	Others	Others
	Calyxin B exhibits potent activity against human HT-1080 fibrosarcoma cells with an ED50 value of 0.69 microM. A methylated product of calyxin A and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups

天然产物

3-Methylcarbazole

Cat.No: T64343

Synonym: NSC 10154

Target: Others

Dihydroniloticin

Cat.No: TN3854

Target: Others

9,10-Dimethoxycanthin-6-one

Cat.No: TN3307

Target: Others

Cat.No: TN3571

Target: Others

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