首页工具

搜索结果

Search Results for " hras "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T32104	Hras-1Y i-motif Probe-1
	Hras-1Y i-motif Probe-1 is a probe of the hras-1Y i-motif which selectively and directly interacts with it.
T8970	ML162	Ferroptosis; GPX; Glutathione Peroxidase	Apoptosis; Metabolism; oxidation-reduction
	ML162 是一种共价谷胱甘肽过氧化物酶 4 抑制剂。它选择性抑制表达突变 RAS 癌基因的细胞系。
T81263	RMC-7977	Ras	GPCR/G Protein; MAPK
	RMC-7977是一种可逆的三重复合RAS抑制剂，对KRAS、NRAS和HRAS的突变型及野生型(WT)变体表现出广谱活性。该化合物能够引发肿瘤消退，在多种依赖RAS的临床前癌症模型中显示出良好的耐受性。此外，RMC-7977还能有效抑制KRASG12C癌瘤模型的生长。[1]
T28733	SCH-53870
	SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.
T64000	MRTX-EX185
	MRTX-EX185 是一种有效的负载 GDP 的 KRAS 和 KRAS (G12D) 抑制剂，对 KRAS (G12D) 的 IC50=90 nM。MRTX-EX185 也能够结合 GDP 负载的 HRAS。
T36641	RAS inhibitor Abd-7
	RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].