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Search Results for " hpd "

Targets Recommended: Others

8

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T19955	Biotin-HPDP Pyridyldisulfide-biotin,Pyridyldithiol-biotin	Others	Others
	Biotin-HPDP (Pyridyldithiol-biotin) 是一种巯基反应性生物素化试剂。
T39588	Human PD-L1 inhibitor IV Human PD-L1 inhibitor IV
	Human PD-L1 inhibitor IV is a polypeptide compound that competitively inhibits the human PD-1 protein. It has a Kd value of 1.38 μM and effectively blocks the interaction between hPD-1 and hPD-L1.
T76080	Human PD-L1 inhibitor V	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	V (human PD-L1 inhibitor) 是一种与human PD-1 protein结合的肽，具有3.32 μM的Kd值，能有效抑制PD-1/PD-L1之间的相互作用。
T76080L	Human PD-L1 inhibitor V TFA
	HumanPD-L1inhibitor V TFA 是一种humanPD-1protein 结合肽，Kd 值为 3.32 μM，可抑制人PD-1/PD-L1的结合。
T69447	APBC
	APBC is a novel PD-L1 inhibitor, effectively interrupting the PD-1/PD-L1 interaction by directly binding to PD-L1, presenting the KD and IC50 values at low-micromolar level, displaying superior antitumor efficacy in hPD-L1 knock-in B16F10-bearing mouse model without the induction of observable liver toxicity.
T79576	PD-1/PD-L1-IN-32	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-32（compound A56）为高效抗PD-1/PD-L1抑制剂，IC50值为2.4 nM，显示出抗癌活性。在hPD-L1 MC38人源化小鼠模型中，该化合物能显著抑制肿瘤生长，同时对小鼠未见明显毒性。
T61968	PD-1/PD-L1-IN 6
	PD-1/PD-L1-IN 6 (compound A13) 是有效的PD-1/PD-L1相互作用抑制剂（IC50为 132.8 nM）。PD-1/PD-L1-IN 6 显示出显著的免疫调节活性。在 Hep3B/OS-8/hPD-L1 与 CD3 T 细胞共培养模型中，PD-1/PD-L1-IN 6显著提高干扰素 -γ 分泌，且无明显毒性作用。在 T 细胞-肿瘤共培养模型中，PD-1/PD-L1-IN 6恢复免疫应答。
T40112	PROTAC PD-1/PD-L1 degrader-1 PROTAC PD-1/PD-L1 degrader-1
	PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.

化合物

Cat.No: T19955

Synonym: Pyridyldisulfide-biotin,Pyridyldithiol-biotin

Target: Others

Human PD-L1 inhibitor IV

Cat.No: T39588

Synonym: Human PD-L1 inhibitor IV

Human PD-L1 inhibitor V

Cat.No: T76080

Target: PD-1/PD-L1

Human PD-L1 inhibitor V TFA

Cat.No: T76080L

Cat.No: T69447

PD-1/PD-L1-IN-32

Cat.No: T79576

Target: PD-1/PD-L1

PD-1/PD-L1-IN 6

Cat.No: T61968

PROTAC PD-1/PD-L1 degrader-1

Cat.No: T40112

Synonym: PROTAC PD-1/PD-L1 degrader-1

Cat. No.	Product Name	Target	Signaling Pathways
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。

天然产物

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04898	PD-1 Protein, Human, Recombinant (hFc) PD1,programmed cell death 1,PD-1,hPD-l,hSLE1,CD279,...	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A0M3M0G7.
TMPY-05079	PD-1 Protein, Human, Recombinant (mFc) PD-1,SLEB2,hSLE1,CD279,programmed cell death 1,hPD-...	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.3 kDa and the accession number is A0A0M3M0G7.
TMPY-00897	PD-1 Protein, Human, Recombinant (His) PD1,hPD-l,hPD-1,CD279,programmed cell deat...	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7.
TMPY-06682	PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His) hPD-1,hSLE1,hPD-l,CD279,PD1,PD-1,programme...	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.65 kDa and the accession number is NP_005009.2.
TMPY-05619	PD-1 Protein, Human, Recombinant (His), Biotinylated hPD-l,PD-1,SLEB2,PD1,hPD-1,programmed cell...	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7.
TMPY-00896	PD-1 Protein, Human, Recombinant (His & hFc) PD1,hPD-l,SLEB2,programmed cell death 1,hSLE1,PD-1,...	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.84 kDa and the accession number is A0A0M3M0G7.
TMPY-06336	PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated SLEB2,hPD-1,programmed cell death 1,PD1,hPD	Human	HEK293 Cells
	PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 44.49 kDa and the accession number is NP_005009.2.
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated Programmed cell death protein 1,PDCD1,CD279,hPD-1	Human	HEK293 Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been sugg...
TMPJ-00938	4HPPD Protein, Human, Recombinant (His) PPD,4HPPD,HPD,4-Hydroxyphenylpyruvate Dioxygenase,H...	Human	E. coli
	4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in h...

重组蛋白

PD-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04898

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05079

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00897

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His)

Cat.No: TMPY-06682

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05619

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00896

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06336

Species: Human

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00181

Species: Human

Expression System: HEK293 Cells

4HPPD Protein, Human, Recombinant (His)

Cat.No: TMPJ-00938

Species: Human

Expression System: E. coli

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