9
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79520 |
HMG-CoA Reductase-IN-1
|
||
HMG-CoA Reductase-IN-1是一种HMG-CoA还原酶抑制剂,显示出高HMGR抑制活性及OATP1B1亲和力,具有pIC50值8.54和pKm值1.98。该化合物适用于高胆固醇血症的研究。 | |||
T38249 |
2-Hydroxy atorvastatin lactone
|
||
2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2]. | |||
T81257 |
Rosuvastatin zinc salt
Rosuvastatin zinc |
||
Rosuvastatin zinc salt (Rosuvastatin zinc),为Rosuvastatin的含锌盐形态,属于HMG-CoA还原酶抑制剂类药物,常用于动脉粥样硬化的研究领域。 | |||
T11572 | HMG499 | HMG-CoA Reductase | Metabolism |
HMG499是有效,选择性的HMG-CoA 还原酶抑制剂,EC50为 0.41 μM。HMG499可消除他汀类药物诱导的HMGCR 积聚,并且降低血清胆固醇水平,减少动脉粥样硬化。 | |||
T61430 | S-2E | ||
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2]. | |||
T78718 | Dim16 | ||
Dim16是一种同时抑制PCSK9和HMG-CoAR的化合物,其对PCSK9的IC50为19 nM,并且能够阻断PCSK9与LDLR的结合,此作用的IC50为0.8 nM。Dim16还能提升HepG2细胞对LDL的吸收。 | |||
T36827 |
Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA |
||
Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5] | |||
T36863 |
Geranylgeranyl Pyrophosphate (ammonium salt)
Geranylgeranyl Pyrophosphate (ammonium salt),GGPP |
||
Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco... | |||
T35718 |
N-desmethyl Rosuvastatin (sodium salt hydrate)
|
||
N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0683 |
Mevastatin
Compactin,ML236B,美伐他汀 |
Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药,可诱导细胞凋亡,将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性,用于心血管疾病的研究。 | |||
T75626 | Ganoderenic acid K | ||
Ganoderenic acid K,一种从灵芝子实体分离得到的天然产物,对HMG-CoA还原酶(HMGCR)显示出强抑制作用,IC50值为16.5 μM。 | |||
T35400 |
β-Muricholic Acid
β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid |
||
β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4] |