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Cat. No.	Product Name	Target	Signaling Pathways
T22022	Adaptaquin	HIF	Angiogenesis; Chromatin/Epigenetic
	Adaptaquin 是缺氧诱导因子脯氨酰羟化酶（HIF-PH）的抑制剂。
T2445	FG-2216 YM-311,FG2216,FG 2216	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。
T5392	TP0463518	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	TP0463518 是缺氧诱导因子脯氨酰羟化酶抑制剂，能够作用于人 PHD2(Ki= 5.3 nM)。它还抑制人PHD1/PHD3，IC50分别为 18 和 63 nM，以及猴 PHD2(IC50=22 nM)。
T1823	IOX2 IOX 2,JICL38	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	IOX2 (IOX 2) 是特异性的脯氨酰羟化酶-2 抑制剂，IC50=22 nM。
T2652	Molidustat BAY 85-3934	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。
T4106	MK-8617 MK8617	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	MK-8617 是一种口服具有活力的低氧诱导因子脯氨酰羟化酶 1-3 (HIF PHD1-3) 泛抑制剂，对于PHD2的IC50=1 nM。
T3180	JNJ-42041935 HIF-PHD Inhibitor II	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	JNJ-42041935 (HIF-PHD Inhibitor II) 是一种高效的，竞争性的、选择性的脯氨酰羟化酶PHD 抑制剂，抑制PHD1(pKi= 7.91±0.04)，PHD2 (pKi= 7.29 ±0.05) 和 PHD3 (pKi= 7.65±0.09)。
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.
T79241	PHD2-IN-1	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD2-IN-1 为一种口服活性强效 HIF-脯氨酰羟化酶2 (PHD2) 抑制剂，具有 22.53 nM 的 IC50 值，适用于贫血病研究。
T61458	HIF-PHD-IN-2
	HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].
T68511	KRH102140
	KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format...