10
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Cat. No. | Product Name | Target | Signaling Pathways |
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T8552 |
PSEM 89S TFA
|
AChR | Neuroscience |
PSEM 89S TFA 是一种脑渗透性和选择性离子通道激动剂,分别对 Q79G 和 L141F 具有正交选择性。 | |||
T78025 |
LQVTDSGLYRCVIYHPP
|
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LQVTDSGLYRCVIYHPP (LP17) 为髓系细胞表达之触发受体 1 (TREM-1) 抑制性肽类化合物,能有效减轻缺血引发的梗塞及神经元损害,并可渗透大脑,阻断TREM-1。 | |||
T11434 |
GlyRS-IN-1
|
Others | Others |
GlyRS-IN-1 is an inhibitor of glycyl-tRNA synthase (GlyRS). It can inhibit the growth of bacteria. | |||
T78026 |
LQVTDSGLYRCVIYHPP TFA
|
||
LQVTDSGLYRCVIYHPP (LP17) TFA 是一种针对髓系细胞表面的触发受体1 (TREM-1) 的抑制肽。该化合物能有效减缓缺血导致的梗塞及神经元损害,并可穿透血脑屏障,阻断 TREM-1的活性。 | |||
T36811 |
uPSEM 817 tartrate
|
||
Selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channel agonist (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM4-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg). Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science 3... | |||
T36810 | uPSEM 792 hydrochloride | ||
Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetra... | |||
T61655 |
AM-1488
|
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AM1488 是一种有效的、具有口服活性的甘氨酸受体 (GlyR) 增效剂 (hGlyRα3EC50=0.45 μM)。 | |||
T37391 |
PSEM 308 hydrochloride
|
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PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels. Recommended concentration for use in mice is 5 mg/kg or lower. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. Lovett-Barron et al (2012) Regulation of neu... | |||
T10618 |
Broflanilide
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Broflanilide 是昆虫抗狄氏剂 GABA 受体拮抗剂,可代谢为 Desmethyl-Broflanilide,抑制斜纹夜蛾 RDL GABAR,IC50值为 1.3 nM。 | |||
T16292 |
NFPS
|
Thrombin | Proteases/Proteasome |
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4811 |
D-Alanine
D-α-Alanine,Ba 2776,(R)-Alanine,D-丙氨酸,(R)-2-Aminopropionic acid |
Chloride channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
D-Alanine ((R)-Alanine) 是一种GlyR 和PMBA 的弱激动剂,其对GlyR 的EC50=9 mM。 | |||
T16533 |
Picrotin
|
Chloride channel | Membrane transporter/Ion channel |
Picrotin 是甘氨酸受体的抑制剂。 Picrotin 阻断 α2 GlyR、α1 GlyR 和 α3 GlyR,可用于神经传递研究。 |