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Search Results for " gtpases "

15

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8473	MLS000532223	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS000532223 是一种具有高亲和力的 Rho 家族 GTPases 选择性抑制剂，其EC50=16~120 μM。它能阻止几种 GTPases 同 GTP 的结合。
T14004	1A-116	Rho	Cell Cycle/Checkpoint
	1A-116 是 Rac1的抑制剂，对几种类型的癌症具有抗肿瘤和抗转移作用，如乳腺癌。
T6634	RBC8	GTPase; Ras	GPCR/G Protein; MAPK
	RBC8是一种特异性 GTP 酶 RalA/RalB 抑制剂，通过抑制 Ral 与其效应物 RALBP1 的结合，对 GTP 酶 RhoA 和 Ras 没有抑制作用。
T21970	ML-097	GTPase	GPCR/G Protein
	ML-097 是 Ras 相关 GTP 酶的泛激活剂。
T7558	CID-1067700 2-[[(苯甲酰基氨基)硫代甲酰]氨基]-4,7-二氢-5,5-二甲基-5H-噻吩并[2,3-C]吡喃-3-羧酸	Ras	GPCR/G Protein; MAPK
	CID-1067700 是泛 GTPase 抑制剂，可竞争性抑制大脑 7 (Rab7) 中的 Ras 相关蛋白，Ki 为 13 nM。
T22991	ML-099	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	ML-099 是广谱的 Ras 相关GTPases 激活剂，对Rac1、cell division cycle 42、Ras、Rab7和Rab-2A 均有激活作用。
T16745	Rhosin hydrochloride	Apoptosis; Rho; Ras	Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	Rhosin hydrochloride 是一种特异性 RhoA 亚家族Rho GTPases 抑制剂，抑制 RhoA-GEF 相互作用。它通过增强 D1 中棘神经元的可塑性和降低过度兴奋性来促进应激恢复，可诱导细胞凋亡。
T22106	MLS-573151	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS-573151 是 GTPase Cdc42 的选择性抑制剂，EC50 为 2 μM。它通过阻止 GTP 与 Cdc42 的结合来发挥作用。
T25529	IMM-01	GTPase	GPCR/G Protein
	IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂，其作用于 Rho GTPase 下游以组装肌动蛋白丝，并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员，从而释放 FH2 结构域以调节肌动蛋白和微管动力学。
T16746	Rhosin	Rho	Cell Cycle/Checkpoint
	Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis.
T37023	MB 0223
	Dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion. Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID:29601815
T36863	Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
	Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco...
TP2287	Rac GTPase fragment	Others	Others
	Rac GTPase fragment is a peptide with the sequence H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH, MW= 1019.15. Rac is a subfamily of the Rho family of GTPases, small signaling G proteins (more specifically a GTPase).
T36740	Guanosine 5’-diphosphate (sodium salt hydrate)
	Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)...
T22014	8-CPT-2Me-cAMP, sodium salt
	8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for activating small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium specifically activates Epac1 with an EC50 value of 2.2 μM, while showing no activation of PKA with an EC50 value greater than 10 μM [1]. Additionally, 8-CPT-2Me-cAMP sodium stimulates the Epac-mediated release of calcium ...

化合物

Cat.No: T8473

Target: Rho, Ras

Cat.No: T14004

Target: Rho

Cat.No: T6634

Target: GTPase, Ras

Cat.No: T21970

Target: GTPase

Cat.No: T7558

Synonym: 2-[[(苯甲酰基氨基)硫代甲酰]氨基]-4,7-二氢-5,5-二甲基-5H-噻吩并[2,3-C]吡喃-3-羧酸

Target: Ras

Cat.No: T22991

Target: Rho, Ras

Rhosin hydrochloride

Cat.No: T16745

Target: Apoptosis, Rho, Ras

Cat.No: T22106

Target: CDK, Ras

Cat.No: T25529

Target: GTPase

Cat.No: T16746

Target: Rho

Cat.No: T37023

Geranylgeranyl Pyrophosphate (ammonium salt)

Cat.No: T36863

Synonym: Geranylgeranyl Pyrophosphate (ammonium salt),GGPP

Rac GTPase fragment

Cat.No: TP2287

Target: Others

Guanosine 5’-diphosphate (sodium salt hydrate)

Cat.No: T36740

8-CPT-2Me-cAMP, sodium salt

Cat.No: T22014

Cat. No.	Product Name	Target	Signaling Pathways
T4897	Inosine-5'-triphosphate trisodium salt ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt	Others; Endogenous Metabolite	Metabolism; Others
	Inosine-5'-triphosphate trisodium salt (ITP) 是三磷酸核苷，能够作为 ATPases 和 GTPases 的底物。
T4969	Guanosine 5'-triphosphate trisodium salt 鸟苷-5'-三磷酸三钠盐,GTP Trisodium salt,5'-GTP trisodium salt	Endogenous Metabolite	Metabolism
	Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) 为G蛋白(G proteins)信号转导过程中的活化剂。

天然产物

Inosine-5'-triphosphate trisodium salt

Cat.No: T4897

Synonym: ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt

Target: Others, Endogenous Metabolite

Guanosine 5'-triphosphate trisodium salt

Cat.No: T4969

Synonym: 鸟苷-5'-三磷酸三钠盐,GTP Trisodium salt,5'-GTP trisodium salt

Target: Endogenous Metabolite

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