Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9987 |
GSK3-IN-1
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK3-IN-1是一种 GSK3B-糖原合酶激酶3β抑制剂。 | |||
T35555 |
GSK-3/CDK5/CDK2-IN-1
GSK-3/CDK5/CDK2-IN-1 |
||
GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1]. | |||
T73270 |
GSK3-IN-2
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK3-IN-2 是一种有效的 GSK3抑制剂。 | |||
T64366 |
GSK3-IN-4
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK3-IN-4是一种 GSK-3抑制剂,对 GSK-3α和 GSK-3β的IC50值为 0.101-1 μM。 | |||
T8969 |
API-1
NSC177223 |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
API-1 (NSC-177223) 是Akt/PKB 抑制剂,可同 PH 结构域相结合并抑制 Akt 膜易位,有效降低 Akt 的磷酸化水平。它可选择性的抑制PKB,对 PKC 和 PKA 的激活无抑制作用。它可以和 TNF 相关的凋亡诱导配体协同作用从而诱导细胞凋亡。 | |||
T74034 | 6-Me-ATP trisodium | ||
6-Me-ATP trisodium (N6-Methyl-ATP) 是N6-修饰的ATP衍生物,展现对GSK3良好的结合亲和力,可作为GSK3β磷酸化底物肽的磷酸基团供体。 | |||
T36689 | KuWal151 | ||
Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations. Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID:29723265 | |||
T74033 | 6-Me-ATP | ||
6-Me-ATP(N6-Methyl-ATP)为ATP的N6修饰衍生物。该化合物与GSK3β结合亲和力显著,能有效作为GSK3β催化底物肽磷酸化的磷酸基团供体。 | |||
T35560 |
SAR502250
|
||
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic... | |||
T79254 |
Antitrypanosomal agent 14
|
Parasite | Microbiology/Virology |
Antitrypanosomal agent 14(Compound 1)是一种针对T. brucei的有效抑制剂,其EC50为0.47 μM。它对TbGSK3的抑制作用表现在IC50为12 μM。该化合物主要用于非洲人类锥虫病的研究。 |