Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40083 |
GLUT inhibitor-1
|
transporter | Metabolism |
GLUT inhibitor-1 是一种具有口服活性的 GLUT 抑制剂,对 GLUT1 和 GLUT3 的 IC50 分别为 242 nM 和 179 nM。 GLUT inhibitor-1 可用于癌症和自身免疫性疾病的研究。 | |||
T4328 |
OSS_128167
SIRT6-IN-1 |
HBV; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂,对 SIRT6,SIRT1 和 SIRT2 的 IC50分别为 89 μM,1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性,可抑制 HBV 的转录和复制。 | |||
T4182 |
lavendustin B
薰草菌素B |
Tyrosinase; transporter; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Lavendustin B 是一种酪氨酸激酶抑制剂,是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。 | |||
T22317 |
DRB18
|
transporter | Metabolism |
DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associated with glucose-related pathways. DRB18 exerts its effects by promoting G1/S phase arrest, increasing oxidative stress, and prompting necrotic cell death, ultimately displaying notable anti-tumor activity [1]. | |||
T8616 |
Fasentin
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide |
transporter | Metabolism |
Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂,可抑制GLUT-1/GLUT-4转运蛋白,优先抑制 GLUT4,IC50为 68 μM。它是死亡受体刺激敏化剂,可敏化细胞对 FAS 诱导的细胞死亡,具有抗血管生成活性。 | |||
T61133 |
SSAO/VAP-1 inhibitor 1
|
||
SSAO/VAP-1 inhibitor 1 是一种有效的SSAO/VAP-1抑制剂。SSAO/VAP-1 促进葡萄糖转运 4 (GLUT 4) 从脂肪细胞转移到细胞膜,从而调节葡萄糖转运。在内皮细胞中,SSAO/VAP-1 可以介导白细胞和内皮细胞的粘附和渗出,并参与炎症反应。SSAO/VAP-1 inhibitor 1 具有研究炎症和/或炎症相关疾病或糖尿病和/或糖尿病相关疾病的潜力。 | |||
T68324 |
KCN1
|
||
KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner. KCN1 potently inhibited the grow... |