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Search Results for " ggf "

Targets Recommended: Proteasome

8

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80101	Z-GGF-CMK	Proteasome	Proteases/Proteasome; Ubiquitination
	Z-GGF-CMK为一种针对ClpP1P2及蛋白酶体的蛋白酶抑制剂，其在HepG2细胞上展现出细胞毒性，具有125 μM的CC50值。
T81834	MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
	MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) 为ADC用途的drug-linker conjugate，其结构包括7ethanol-10NH2-11F-Camptothecin 与蛋白酶可降解(cleavable)的MC-GGFG通过化学键连接形成。
T75134	MC-GGFG-AM-(10Me-11F-Camptothecin)
	MC-GGFG-AM-(10Me-11F-Camptothecin) 是ZW251合成的Linker-Payload偶联物。ZW251是靶向人GPC3的抗体-活性分子偶联物(ADC)，包括人源化IgG1抗体、喜树碱(camptothecin)类的扑异构酶1抑制剂ZD06519及连接子（马来酰亚胺锚定和甘酰甘酰苯丙酰甘氨酸(GGFG)-氨基甲基(AM)可切割连接体）。该药物对人和食蟹猴GPC3具高亲和力，在表达GPC3的HCC细胞系中快速内化并可对GPC3阴性癌细胞进行旁观者介导杀伤。
T77886	GGFG-amide-glycol-amide-Exatecan
	GGFG-amide-glycol-amide-Exatecan(Intermediate 2)为Exatecan衍生物，适用于合成抗体药物偶联物(ADC)。
T82323	GGFG-Eribulin
	GGFG-Eribulin（Compound GGFG）是一种用于合成ADCs的ADC-药物连接子偶联物。它由ADC细胞毒素Exatecan和连接子构成，以实现靶向输送药物。
T16024	MC-GGFG-DX8951	Others	Others
	MC-GGFG-DX8951 is a drug-linker conjugate designed for antibody-drug conjugation (ADC) that demonstrates antitumor activity through the deployment of DX8951, a DNA topoisomerase I inhibitor, connected using the protease-cleavable MC-GGFG linker[1].
T77891	Propargyl-PEG4-GGFG-DXd
	Propargyl-PEG4-GGFG-DXd 作为抗体偶联活性分子（drug-linker conjugate for ADC）的组成部分，整合了一个可降解的ADC linker与 DNAtopoisomerase I 抑制剂 DXd。
T81833	MC-GGFG-AM-(10NH2-11F-Camptothecin)
	MC-GGFG-AM-(10NH2-11F-Camptothecin) 是一种ADC，其通过pH敏感的可水解连接物与Trop-2针对性抗体sacituzumab偶联，展现出针对癌症的活性，适用于癌症研究领域。

化合物

Cat.No: T80101

Target: Proteasome

MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)

Cat.No: T81834

MC-GGFG-AM-(10Me-11F-Camptothecin)

Cat.No: T75134

GGFG-amide-glycol-amide-Exatecan

Cat.No: T77886

GGFG-Eribulin

Cat.No: T82323

MC-GGFG-DX8951

Cat.No: T16024

Target: Others

Propargyl-PEG4-GGFG-DXd

Cat.No: T77891

MC-GGFG-AM-(10NH2-11F-Camptothecin)

Cat.No: T81833

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02721	NRG1 alpha Protein, Human, Recombinant (His) HRGA,NDF,neuregulin 1,SMDF,NRG1 α,NRG1-IT2,GGF2,	Human	HEK293 Cells
	NRG1 alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.5kDa and the accession number is Q02297-1.
TMPY-03010	NRG1 beta 1 Protein, Human, Recombinant NDF,GGF,MSTP131,Neuregulin 1,MST131,ARIA,NRG1-IT2,S...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
TMPY-00479	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) ARIA,neuregulin 1,GGF2,MSTP131,GGF,MST131,...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12.
TMPY-05813	Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated HGL,NRG1-IT2,MST131,NDF,SMDF,neuregulin 1,HRG,GGF,<...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297.
TMPY-00031	Neuregulin-1/NRG1 Protein, Human, Recombinant (His) HRG1,GGF2,HRG,NDF,MSTP131,HRGA,GGF,neuregu...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is Q02297-12.
TMPY-02600	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) neuregulin 1,HRGA,NRG1 β1,HGL,MST131,MSTP131,HRG,ARIA,NDF,	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is Q02297-6.
TMPY-02705	NRG1 beta 1 Protein, Human, Recombinant (hFc) MSTP131,HRG1,NRG1-IT2,ARIA,HGL,SMDF,GGF,HRG,NDF,MST...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.
TMPY-02719	NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) HRG1,NRG1-IT2,HRGA,NRG1 α,HGL,neuregulin 1,SMDF,MSTP131,NDF,...	Human	HEK293 Cells
	NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1.
TMPY-02720	NRG1 alpha Protein, Human, Recombinant (hFc) MST131,HRG1,NRG1 α,SMDF,NRG1-IT2,GGF2,HRGA,NDF,ARIA...	Human	HEK293 Cells
	NRG1 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 51 kDa and the accession number is Q02297-1.
TMPJ-00448	NRG1 beta 1 Protein, Human, Recombinant (aa 2-246) NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1...	Human	E. coli
	Pro-neuregulin-1,Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ...

重组蛋白

NRG1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-02721

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant

Cat.No: TMPY-03010

Species: Human

Expression System: HEK293 Cells

Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00479

Species: Human

Expression System: HEK293 Cells

Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated

Cat.No: TMPY-05813

Species: Human

Expression System: HEK293 Cells

Neuregulin-1/NRG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00031

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)

Cat.No: TMPY-02600

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02705

Species: Human

Expression System: HEK293 Cells

NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc)

Cat.No: TMPY-02719

Species: Human

Expression System: HEK293 Cells

NRG1 alpha Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02720

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

Cat.No: TMPJ-00448

Species: Human

Expression System: E. coli

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