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Search Results for " fatty acid-binding protein "

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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4534	BMS-309403	FABP	Metabolism
	BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白 aFABP 抑制剂。它可改善载脂蛋白 E 缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。
T68586	STK-15
	STK-15 is a novel Fatty Acid Binding Protein 5 (FABP5) Inhibitor.
T68589	STK-22
	STK-22 is a novel Fatty Acid Binding Protein 5 (FABP5) Inhibitor.
T30526	BMS-480404 BMS 480404,BMS480404,UNII-T78485CEYD
	BMS-480404 is an effective small molecule inhibitor, which can bind to human keratinocyte fatty acid-binding protein.
T15506	HTS01037	Others	Others
	HTS01037 is an inhibitor of fatty acid-binding. HTS01037 is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).
T40980	Palmitic acid-13C2 Palmitic acid-13C2
	Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
T16322	Nicodicosapent	Others	Others
	Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, H
T40141	Palmitic acid-13C16 sodium Palmitic acid-13C16 sodium
	Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells.
T39423	Palmitic acid-13C sodium
	Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granulosa cells.
T78391	DAUDA
	DAUDA (11-(dansylamino) undecanoic acid)是一种荧光脂肪酸类似物，对环境变化敏感。该分子通过调整其发射强度和荧光光谱与结合蛋白发生相互作用。在研究中，DAUDA用于评估天然脂肪酸与曼氏血吸虫Sm14脂肪酸结合蛋白多晶型的相对亲和力。
T37614	LDN-0088050
	LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1]. Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1]Kd: 2.05 μM (FABP4)[1] LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1]. [1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biolo...
T63355	BMS-309403 sodium
	BMS-309403 sodium 是一种有效的选择性脂肪细胞脂肪酸结合蛋白aFABP, 也称为FABP4，aP2抑制剂，对 FABP4，FABP3 和 FABP5 的Ki 分别为 <2 nM，250 nM，350 nM。BMS-309403 sodium 与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。BMS-309403 sodium 可改善载脂蛋白E 缺乏症小鼠和培养的人内皮细胞的内皮功能。
T69824	PSB-17365
	PSB-17365 is a potent GPR84 agonist. PSB-17365 exhibits EC50 values vs. GPR84 of 2.5nM in a cAMP accumulation assay, and 100nM in a β-arrestin 2 recruitment assay. No direct binding affinities are provided. PSB-17365 is selective for GPR84 compared to other free fatty acid receptors (FFAR1 and FFAR4). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.
T38070	Arachidonic Acid-biotin
	Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signalling and inflammation. Arachidonic acid-biotin was designed to allow arachidonic acid to be detected in complex...
T70006	DHA-paclitaxel
	DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the func...
T76550	CooP
	CooP为一种针对线性胶质母细胞瘤的九肽，与胶质母细胞瘤细胞及其相关血管系统中的乳腺来源生长抑制剂/脂肪酸结合蛋白3 (FABP3) 发生结合。该化合物主要应用于化学疗法和多种纳米粒子的靶向递送。
T36956	Bis-ANS dipotassium 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid,bis-ANS (potassium salt)
	bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation.[1] Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.[2] bis-ANS has an excitation maxima of 390 nm.[3] It has an emission maximum of 523 nm when free in solution but undergoes a blue shift with an increase in fluorescence intensity when bound to protein; for example, when bound to intestinal fatty acid binding protein (FAPB2) it has emission maxima...
T36939	PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transd...
T37896	AZ 1729
	FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro. Bolognini et al (2016) A novel...

化合物

Cat.No: T4534

Target: FABP

Cat.No: T68586

Cat.No: T68589

Cat.No: T30526

Synonym: BMS 480404,BMS480404,UNII-T78485CEYD

Cat.No: T15506

Target: Others

Palmitic acid-13C2

Cat.No: T40980

Synonym: Palmitic acid-13C2

Cat.No: T16322

Target: Others

Palmitic acid-13C16 sodium

Cat.No: T40141

Synonym: Palmitic acid-13C16 sodium

Palmitic acid-13C sodium

Cat.No: T39423

Cat.No: T78391

Cat.No: T37614

BMS-309403 sodium

Cat.No: T63355

Cat.No: T69824

Arachidonic Acid-biotin

Cat.No: T38070

Cat.No: T70006

Cat.No: T76550

Bis-ANS dipotassium

Cat.No: T36956

Synonym: 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid,bis-ANS (potassium salt)

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat.No: T36939

Synonym: PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat.No: T37896

Cat. No.	Product Name	Target	Signaling Pathways
T72152	Eicosapentaenoic Acid sodium 二十碳五烯酸钠盐,Timnodonic acid sodium,EPA sodium
	Eicosapentaenoic Acid (EPA) sodium 为口服活性 ω-3 长链多不饱和脂肪酸 (ω-3 LC-PUFAs)。其通过DNA去甲基化，促进肿瘤抑制基因CCAAT/增强子结合蛋白δ (C/EBPδ)的重新表达，并通过H-RAS内含子1 CpG岛的去甲基化，激活U937白血病细胞中RAS/ERK/C/EBPβ途径。此外，该化合物能够促进血管平滑肌细胞松弛和血管舒张。

天然产物

Eicosapentaenoic Acid sodium

Cat.No: T72152

Synonym: 二十碳五烯酸钠盐,Timnodonic acid sodium,EPA sodium

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