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Targets Recommended: Apoptosis IAP Caspase Topoisomerase p53

1

抑制剂 & 化合物

4

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T16522 Phenoxodiol

脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Apoptosis; IAP; Caspase; Topoisomerase; p53 Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
Phenoxodiol (Idronoxil) 是合成genestein 的类似物,激活线粒体caspase 系统,抑制XIAP,使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞,通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II,从而阻止DNA 复制。

化合物

Phenoxodiol
Cat.No: T16522
Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E
Target: Apoptosis, IAP, Caspase, Topoisomerase, p53
Cat. No. Product Name Species Expression System
TMPH-01057 Caspase-8 Protein, Human, Recombinant (His)

Caspase-8,CAP4,Apoptotic cysteine protease,FLICE,FA...

Human E. coli
Caspase-8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is Q14790.
TMPH-01315 CASR Protein, Human, Recombinant (GST)

CAP4,MCH5,Caspase-8,CASP-8,CASP8,FADD-homologous ICE/ced-3-l...

Human E. coli
CASR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 93.6 kDa and the accession number is P41180.
TMPJ-01256 Caspase-10 Protein, Human, Recombinant (His)

CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co...

Human E. coli
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPY-02213 RAIDD Protein, Human, Recombinant (His)

RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d...

Human E. coli
Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ...

重组蛋白

Caspase-8 Protein, Human, Recombinant (His)
Cat.No: TMPH-01057
Species: Human
Expression System: E. coli
CASR Protein, Human, Recombinant (GST)
Cat.No: TMPH-01315
Species: Human
Expression System: E. coli
Caspase-10 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01256
Species: Human
Expression System: E. coli
RAIDD Protein, Human, Recombinant (His)
Cat.No: TMPY-02213
Species: Human
Expression System: E. coli
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