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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11266L	FAS-IN-1 Tosylate	Fatty Acid Synthase	Metabolism
	FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM.
T11266	FASN-IN-4 FAS-IN-1	Others	Others
	FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM.
TQ0220	KR-33493 KR-33494,KM-819	Fas/FasL	Apoptosis
	KR-33493 是一种 FAS 相关因子 1 (FAF1) 抑制剂，可用于帕金森病研究。
T14570	BI 99179 BI99179	Fatty Acid Synthase	Metabolism
	BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].
T36331	Z-AEVD-FMK Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
	Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 &#181M, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。
T64171	LXR antagonist 2
	LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂，能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂，能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。
T36130	22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22...

化合物

FAS-IN-1 Tosylate

Cat.No: T11266L

Synonym:

Target: Fatty Acid Synthase

FASN-IN-4

Cat.No: T11266

Synonym: FAS-IN-1

Target: Others

KR-33493

Cat.No: TQ0220

Synonym: KR-33494,KM-819

Target: Fas/FasL

BI 99179

Cat.No: T14570

Synonym: BI99179

Target: Fatty Acid Synthase

Z-AEVD-FMK

Cat.No: T36331

Synonym: Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

22(S)-hydroxy Cholesterol

Cat.No: T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TJS0387	Desoxyrhaponticin 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin	Apoptosis; Fatty Acid Synthase	Apoptosis; Metabolism
	Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂，抑制细胞内 FAS 活性，下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。
T3S1775	Tectochrysin NSC 80687,Techtochrysine,Techtochrysin,柚木柯因	NF-κB; STAT	JAK/STAT signaling; NF-κB; Stem Cells
	Tectochrysin (Techtochrysine) 是Alpinia oxyphylla 的主要黄酮类化合物之一，能够抑制NF-κB 活性。

天然产物

Desoxyrhaponticin

Cat.No: TJS0387

Synonym: 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin

Target: Apoptosis, Fatty Acid Synthase

Tectochrysin

Cat.No: T3S1775

Synonym: NSC 80687,Techtochrysine,Techtochrysin,柚木柯因

Target: NF-κB, STAT

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