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Targets Recommended: EGFR

7

抑制剂 & 化合物

25

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8751 AZD8931 diFuMaric acid

4-[[4-[(3-氯-2-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]氧基]-N-甲基-1-哌啶乙酰胺二富马酸盐

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
AZD8931 diFuMaric acid 是一种可逆的 ATP 竞争性 EGFR、ErbB2 和 ErbB3 抑制剂(IC50 分别为 4 nM、3 nM 和 4 nM)。
T5410 PD158780

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
PD158780是一种EGFR 家族抑制剂,对EGFR、ErbB2、ErbB3ErbB4的IC50值分别为8 μM、49、52 和 52 nM。
T6092 Sapitinib

沙普替尼,AZD-8931

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Sapitinib (AZD-8931) 是可逆的 ATP 竞争型 EGFR 抑制剂,对 EGFR、ErbB2 和 ErbB3的IC50值分别为4、3 和 4 nM。
T76818 Lumretuzumab

Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody)为人源化抗HER3 (ERBB3)单克隆抗体,应用于癌症研究。
T77044 Istiratumab

Istiratumab (M-6495) 是靶向IGF-1R 和ErbB3的双特异性单克隆抗体。Istiratumab 通过蛋白酶体途径诱导IGF-1R 和 ErbB3 受体降解。Istiratumab 可用于癌症研究。
T76918 Barecetamab

Barecetamab (ISU-104) 是一种人源话抗 ErbB3单克隆抗体。Barecetamab 可用于复发/转移性 (R/M) 头颈部鳞状细胞癌 (HNSCC) 的研究。
T80604 Duligotuzumab

RG 7597,MEHD-7945A

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Duligotuzumab (MEHD-7945A; RG 7597)为一种人源化IgG-κ单克隆抗体,具有针对Her3 (ErbB3) 的特异性靶向能力。

化合物

AZD8931 diFuMaric acid
Cat.No: T8751
Synonym: 4-[[4-[(3-氯-2-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]氧基]-N-甲基-1-哌啶乙酰胺二富马酸盐
Target: EGFR
PD158780
Cat.No: T5410
Synonym:
Target: EGFR
Sapitinib
Cat.No: T6092
Synonym: 沙普替尼,AZD-8931
Target: EGFR
Lumretuzumab
Cat.No: T76818
Synonym:
Target:
Istiratumab
Cat.No: T77044
Synonym:
Target:
Barecetamab
Cat.No: T76918
Synonym:
Target:
Duligotuzumab
Cat.No: T80604
Synonym: RG 7597,MEHD-7945A
Target: EGFR
Cat. No. Product Name Species Expression System
TMPY-00399 HER3/ERBB3 Protein, Human, Recombinant

LCCS2,c-erbB-3,HER3,p180-ErbB...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.
TMPY-01389 HER3/ERBB3 Protein, Human, Recombinant (His)

MDA-BF-1,EEBB3,erbB3-S,p45-sE...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPY-04956 HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated

MDA-BF-1,c-erbB-3,HER3,p85-sE...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPY-02365 HER3/ERBB3 Protein, Mouse, Recombinant (His)

Erbb-3r,Erbb3r,erb-b2 re...

Mouse HEK293 Cells
HER3/ERBB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70 kDa and the accession number is Q61526.
TMPY-03761 HER3/ERBB3 Protein, Human, Recombinant (mFc)

c-erbB-3,c-erbB3,HER...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95 kDa and the accession number is P21860-1.
TMPY-00795 HER3/ERBB3 Protein, Human, Recombinant (hFc)

HER3,c-erbB-3,p180-ErbB<...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.
TMPY-05753 HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated

HER3,p180-ErbB3,MDA-BF-1,erbB...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.
TMPK-00453 HER3/ERBB3 Protein, Human, Recombinant (His & Avi)

p45-sErbB3,MDA-BF-1,ErbB-3

Human HEK293 Cells
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession number is P21860-1.
TMPY-06631 HER3/ERBB3 Protein, Human, Recombinant (His & Avi), Biotinylated

c-erbB3,MDA-BF-1,ErbB-3,...

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.93 kDa and the accession number is NP_001973.2.
TMPY-00246 HER3/ERBB3 Protein, Rhesus, Recombinant

erb-b2 receptor tyrosine kinase 3

Rhesus HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.5 kDa and the accession number is XP_001113953.2.
TMPK-01280 HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

p85-sErbB3,HER3,LCCS2,p180-Er...

Cynomolgus,Rhesus HEK293 Cells
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 69.54 kDa and the accession number i...
TMPK-00452 HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled

LCCS2,HER3c-erbB-3,p180-ErbB<...

Human HEK293 Cells
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession numbe...
TMPY-03024 HER3/ERBB3 Protein, Rat, Recombinant (His)

erb-b2 receptor tyrosine kinase 3

Rat HEK293 Cells
HER3/ERBB3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.9 kDa and the accession number is A6KSF8.
TMPY-04541 HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST)

c-erbB3,ErbB-3,p45-s...

Human Baculovirus Insect Cells
HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65 kDa and the accession number is P21860-1.
TMPY-06658 HER3/ERBB3 Protein, Mouse, Recombinant (hFc)

Erbb3,C76256,Erbb-3,erb-...

Mouse HEK293 Cells
HER3/ERBB3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.23 kDa and the accession number is Q61526.
TMPY-02477 HER3/ERBB3 Protein, Rhesus, Recombinant (His)

erb-b2 receptor tyrosine kinase 3

Rhesus HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is XP_005571238.1&XP_001113953.2.
TMPY-06659 HER3/ERBB3 Protein, Mouse, Recombinant (His & Avi), Biotinylated

C76256,Her3,Erbb-3,Erbb<...

Mouse HEK293 Cells
HER3/ERBB3 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.76 kDa and the accession number is Q61526.
TMPJ-00899 HER3/ERBB3 Protein, Human, Recombinant (aa 20-331, hFc)

HER3,Proto-oncogene-like protein c-ErbB-

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (aa 20-331, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 65 KDa and the accession number is P21860-3.
TMPJ-00413 HER3/ERBB3 Protein, Human, Recombinant (aa 20-643, His & Avi), Biotinylated

Proto-oncogene-like protein c-ErbB-3,HER

Human HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (aa 20-643, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 90-120 KDa and the accession number is P21860.
TMPY-03023 HER3/ERBB3 Protein, Rat, Recombinant (hFc)

erb-b2 receptor tyrosine kinase 3

Rat HEK293 Cells
HER3/ERBB3 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.5 kDa and the accession number is A6KSF8.
TMPY-02478 HER3/ERBB3 Protein, Rhesus, Recombinant (hFc)

erb-b2 receptor tyrosine kinase 3

Rhesus HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.7 kDa and the accession number is XP_001113953.2.
TMPY-06660 HER3/ERBB3 Protein, Rhesus, Recombinant (His & Avi), Biotinylated

erb-b2 receptor tyrosine kinase 3

Rhesus HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.92 kDa and the accession number is XP_001113953.2.
TMPY-02708 NRG4 Protein, Human, Recombinant

HRG4,neuregulin 4

Human E. coli
NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including cardiac development, Schwann cell, and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular s...
TMPJ-00448 NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1...

Human E. coli
Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ...
TMPY-02844 EBP1 Protein, Human, Recombinant (His)

proliferation-associated 2G4,EBP1,p38-2G4,HG4-1

Human E. coli
EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its int...

重组蛋白

HER3/ERBB3 Protein, Human, Recombinant
Cat.No: TMPY-00399
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01389
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-04956
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02365
Species: Mouse
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-03761
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00795
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05753
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00453
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06631
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant
Cat.No: TMPY-00246
Species: Rhesus
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
Cat.No: TMPK-01280
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled
Cat.No: TMPK-00452
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Rat, Recombinant (His)
Cat.No: TMPY-03024
Species: Rat
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST)
Cat.No: TMPY-04541
Species: Human
Expression System: Baculovirus Insect Cells
HER3/ERBB3 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-06658
Species: Mouse
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-02477
Species: Rhesus
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06659
Species: Mouse
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (aa 20-331, hFc)
Cat.No: TMPJ-00899
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Human, Recombinant (aa 20-643, His & Avi), Biotinylated
Cat.No: TMPJ-00413
Species: Human
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03023
Species: Rat
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant (hFc)
Cat.No: TMPY-02478
Species: Rhesus
Expression System: HEK293 Cells
HER3/ERBB3 Protein, Rhesus, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06660
Species: Rhesus
Expression System: HEK293 Cells
NRG4 Protein, Human, Recombinant
Cat.No: TMPY-02708
Species: Human
Expression System: E. coli
NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)
Cat.No: TMPJ-00448
Species: Human
Expression System: E. coli
EBP1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02844
Species: Human
Expression System: E. coli
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