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HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST)

产品编号 TMPY-04541

别名: c-erbB3, ErbB-3, p45-sErbB3, LCCS2, p85-sErbB3, HER3, EEBB3, MDA-BF-1, p180-ErbB3, c-erbB-3, erbB3-S, erb-b2 receptor tyrosine kinase 3

HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65 kDa and the accession number is P21860-1.

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HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST)

规格	价格/CNY		货期	数量
50 μg	￥ 4,460		5日内发货

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参考文献

生物活性	1. No Kinase Activity 2. Using the Octet RED System, the affinity constant (Kd) of human ErBB3-GST bound to human NRG1 (aa 2-224) was 20 nM.
产品描述	HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65 kDa and the accession number is P21860-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	His, GST
蛋白编号	P21860-1
别名	c-erbB3, ErbB-3, p45-sErbB3, LCCS2, p85-sErbB3, HER3, EEBB3, MDA-BF-1, p180-ErbB3, c-erbB-3, erbB3-S, erb-b2 receptor tyrosine kinase 3
蛋白构建	The cytoplasmic domain (Pro 730-Ser 1065) of Human ErbB3 (NP_001973.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
蛋白纯度	> 75 % as determined by SDS-PAGE
分子量	65 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, pH 7.5, 10% gly, 1 mM GSH. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Kraus M.H.,et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197. 2. Plowman G.D.,et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909. 3. Katoh M.,et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.

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Keywords

HER3/ERBB3 Protein, Human, Recombinant (aa 730-1065, His & GST) c-erbB3 ErbB-3 EEBB-3 p45-sErbB3 LCCS 2 LCCS-2 EEBB 3 LCCS2 p85-sErbB3 HER3 EEBB3 HER-3 MDA-BF-1 p180-ErbB3 c-erbB-3 HER 3 erbB3-S erb-b2 receptor tyrosine kinase 3 recombinant recombinant-proteins proteins protein

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