Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35528 |
TD52
|
Apoptosis; Phosphatase; Akt | Apoptosis; Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling |
TD52 是 PP2A (CIP2A) 癌性抑制剂的口服活性抑制剂。 TD52 是厄洛替尼衍生物,通过干扰 Elk1 与 CIP2A 启动子的结合间接降低了 CIP2A。 | |||
T72956 |
Darizmetinib
HRX215 |
MAPK | MAPK |
Darizmetinib (HRX215) 是一种 MKK4 抑制剂,MKK4 的抑制导致 MKK7 和 JNK1 信号通路的增强,进而激活转录因子 ATF2 和 ELK1,促进细胞增殖和肝再生。 | |||
T35528L |
TD52 dihydrochloride
TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl |
Others | Others |
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti... | |||
TP2157L |
TAT-DEF-Elk-1 TFA (1220751-16-5 free base)
TDE TFA,TAT-DEF-Elk-1 TFA |
Others | Others |
TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 act | |||
TP2157 |
TAT-DEF-Elk-1
TDE |
Others | Others |
TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor. |