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Search Results for " eif4g "

Targets Recommended: PERK

4

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14044	4E2RCat	PERK	Apoptosis
	4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂，IC50为13.5 μM。
T1742	4E1rcat	PERK; Autophagy	Apoptosis; Autophagy
	4E1RCat 是 cap 依赖性翻译抑制剂，可抑制 eIF4 g 与 eIF4E 的结合，IC50 为 3.2 μM。
T2665	4EGI-1 4EGI 1	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	4EGI-1 是一种竞争性 eIF4E/eIF4 g 相互作用抑制剂，与 eIF4E 结合，Kd 值为 25 μM。
T37099	(Z)-4EGI-1
	(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. [1]. Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E/eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77. [2]. Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E/...

化合物

Cat.No: T14044

Target: PERK

Cat.No: T1742

Target: PERK, Autophagy

Cat.No: T2665

Synonym: 4EGI 1

Target: Apoptosis, PERK, Autophagy

Cat.No: T37099

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His) EIF4G,eIF-4-gamma 1,Eukaryotic tr...	Human	P. pastoris (Yeast)
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is Q04637.
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) eIF-4G 1,EIF4G,Eukaryoti...	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession nu...
TMPY-01769	4EBP1 Protein, Human, Recombinant (His) 4E-BP1,eukaryotic translation initiation factor 4E binding p...	Human	E. coli
	The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, a...
TMPY-06821	THRB Protein, Human, Recombinant (His) THRB1,GRTH,THR1,ERBA2,C-ERBA-2,THRB2,thyroid hormone recepto...	Human	E. coli
	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present...

重组蛋白

EIF4G1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01313

Species: Human

Expression System: P. pastoris (Yeast)

EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)

Cat.No: TMPH-01312

Species: Human

Expression System: E. coli

4EBP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01769

Species: Human

Expression System: E. coli

THRB Protein, Human, Recombinant (His)

Cat.No: TMPY-06821

Species: Human

Expression System: E. coli

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