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Search Results for " eif4f "

Targets Recommended: PERK Autophagy

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T5173	SBI-0640756 SBI 0640756,SBI-756	PERK; Autophagy	Apoptosis; Autophagy
	SBI-0640756 (SBI-756) 是一种靶向 eIF4G1 并破坏 eIF4F 复合物的抑制剂。
T27330	FL3
	FL3 is a novel potent eIF4F inhibitor, it induces the death of cancer cells by an original mechanism that involves the apoptosis-inducing factor and caspase 12.
T73001	eIF4A3-IN-9
	eIF4A3-IN-9 是silvestrol 类似物。eIF4A3-IN-9 干扰eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 29，450 和 80 nM。eIF4A3-IN-9 可用于人类肿瘤发病机制的研究。
T72943	eIF4A3-IN-17
	eIF4A3-IN-17 是 silvestrol 类似物。eIF4A3-IN-17 干扰 eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50值分别为 0.9，15 和 1.8 nM。eIF4A3-IN-17 可用于人类肿瘤发病机制的研究。
T72944	eIF4A3-IN-18
	eIF4A3-IN-18 是silvestrol 类似物。eIF4A3-IN-18 干扰eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 0.8、35 和 2 nM。eIF4A3-IN-18 对 RMPI-8226 细胞具有细胞毒性，LC50值为 0.06 nM。eIF4A3-IN-18 可用于人类肿瘤发病机制的研究。

化合物

SBI-0640756

Cat.No: T5173

Synonym: SBI 0640756,SBI-756

Target: PERK, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01307	EIF4A2 Protein, Human, Recombinant (GST) EIF4A2,eIF4A-II,Eukaryotic initiation fact...	Human	E. coli
	EIF4A2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.4 kDa and the accession number is Q14240.
TMPJ-00507	EIF4E Protein, Human, Recombinant eIF-4F 25 kDa subunit,EIF4F	Human	E. coli
	Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners.It can recognize and bind the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facil...
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His) EIF4G,eIF-4-gamma 1,Eukaryotic translation...	Human	P. pastoris (Yeast)
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is Q04637.
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) eIF-4G 1,EIF4G,Eukaryotic translation init...	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession nu...
TMPJ-01109	EIF4EBP2 Protein, Human, Recombinant (His) Eukaryotic Translation Initiation Factor 4E-Binding Protein ...	Human	E. coli
	Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly into the eIF4F complex, mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. This regulation of is associated to cell proliferation, cell differentiation and viral infection. Phosphorylated EIF4E...
TMPH-01306	EIF4A1 Protein, Human, Recombinant (His & Myc) eIF4A-I,EIF4A1,eIF-4A-I,Eukaryoti...	Human	E. coli
	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. EIF4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The ...
TMPH-01282	ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4	Human	E. coli
	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th...