Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17879 |
E3 ligase Ligand 8
|
Others; Ligand for E3 Ligase | Others; PROTAC |
E3 ligase Ligand 8 是 E3 泛素连接酶配体。它能够利用 linker 与靶蛋白配体连接,形成 PROTAC 分子。PROTAC 可诱导促癌蛋白发生泛素化降解。 | |||
T9809 |
E3 ligase Ligand 23
|
Ligand for E3 Ligase | PROTAC |
E3 ligase Ligand 23 是一种 cereblon 结合剂,可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。 | |||
T7753 |
Thalidomide-O-COOH
Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T17877 |
VH032-cyclopropane-F
VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 |
Others; Ligand for E3 Ligase | Others; PROTAC |
VH032-cyclopropane-F (Phenolic VH101) 是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子,如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。 | |||
T7758 |
Thalidomide-O-amido-PEG3-C2-NH2 TFA
E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA) |
Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) 包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T17920 |
(S,R,S)-AHPC-PEG1-N3
VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) 是 E3 连接酶配体和linker 连接得到的 偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。 | |||
T7760 |
Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA |
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T17924 |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6 |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成分子。 | |||
T17909 |
(S,R,S)-AHPC-PEG3-N3
VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12 |
Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T17922 |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) 是一种 E3 ligase ligand-linker conjugate,包含了 (S,R,S)-AHPC-based VHL ligand 和 3-unit PEG linker。 | |||
T40002 |
Pomalidomide-C3-NH2 hydrochloride
|
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Pomalidomide-C3-NH2 hydrochloride 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T9381 |
Thalidomide 5-fluoride
2-(2,6-二氧代 - 哌啶-3-基)-5-氟 - 异吲哚-1,3-二酮,H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- |
Ligand for E3 Ligase | PROTAC |
Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) 是一种基于沙利度胺的 Cereblon 配体,通过 linker 与 IRAK4 蛋白配体结合形成 PROTACIRAK4 degrader-1。 | |||
T17871 |
E3 ligase Ligand 13
|
Others | Others |
E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | |||
T17868 |
E3 ligase Ligand 10
|
Others | Others |
E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1]. | |||
T17880 |
E3 ligase Ligand 9
|
Others | Others |
E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of cancer-promoting proteins through ubiquitination-mediated mechanisms[1]. | |||
T17876 |
E3 ligase Ligand 18
|
Others | Others |
E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-mediated degradation, targeting cancer-promoting proteins[1]. | |||
T17872 |
E3 ligase Ligand 14
|
Others | Others |
E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of cancer-promoting proteins[1]. | |||
T17894 |
cIAP1 Ligand-Linker Conjugates 3
E3 ligase Ligand-Linker Conjugates 40 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1]. | |||
T9401 |
Thalidomide-NH-PEG1-NH2 hydrochloride
4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T17915 |
Thalidomide-O-amido-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 3,E3 Ligase Ligand-Linker Conjugates 14 |
Others | Others |
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate which is designed using Thalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is synthesized specifically for utilization in PROTAC technology. | |||
T17925 |
(S,R,S)-AHPC-PEG2-NH2
VH032-PEG2-NH2,VHL Ligand-Linker Conjugates 3,E3 ligase Ligand-Linker Conjugates 6 Free Base |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。 | |||
T17883 |
Pomalidomide-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 30 |
Others; PROTAC Linker | Others; PROTAC |
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 3 单元 PEG 的linker。 | |||
T17914 |
Thalidomide-O-amido-C3-COOH
Cereblon Ligand-Linker Conjugates 7,E3 ligase Ligand-Linker Conjugates 15 |
Others | Others |
Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology. | |||
T18553 |
Pomalidomide-amido-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 22,E3 ligase Ligand-Linker Conjugates 55 |
Others | Others |
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1] | |||
T9382 |
Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739。 | |||
T17923 |
(S,R,S)-AHPC-PEG3-NH2
E3 ligase Ligand-Linker Conjugates 5 Free Base,VH032-PEG3-NH2,VHL Ligand-Linker Conjugates 1 |
Others | Others |
(S,R,S)-AHPC-PEG3-NH2 is a synthetic conjugate of an E3 ligase ligand-linker, incorporating the (S,R,S)-AHPC VHL ligand and a 3-unit PEG linker, which are utilized in PROTAC technology. | |||
T40031 |
Thalidomide-O-C6-NH2 hydrochloride
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride,萨力多胺-O-C6-氨基盐酸盐 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) 是一种合成的E3 连接酶配体 -linker 偶联物,用于 PROTAC dTAG-13 的合成。其中 dTAG-13 是一种 FKBP12F36V 和 BET 的降解剂。 | |||
T17912 |
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl
VHL Ligand-Linker Conjugates 11,E3 ligase Ligand-Linker Conjugates 11 |
Others | Others |
(S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. | |||
T17882 |
Pomalidomide-PEG3-C2-NH2 (TFA)
Cereblon Ligand-Linker Conjugates 5 (TFA),E3 ligase Ligand-Linker Conjugates 30 (TFA),Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base) |
Others | Others |
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | |||
T17875 |
Pomalidomide-C2-NH2
Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T40023 |
Pomalidomide-PEG3-CO2H
Thalidomide-NH-PEG3-propionic acid |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) 是一种由 E3 连接酶配体和连接体组成的偶联物,结合了基于 Thalidomide 的 Cereblon 配体和 3 个单元 PEG Linker。 | |||
T40016 |
Thalidomide-NH-CH2-COOH
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T39804 |
Pomalidomide-PEG3-azide
Pomalidomide-PEG3-azide |
||
Pomalidomide-PEG3-azide is a chemically synthesized conjugate comprised of a cereblon ligand based on Pomalidomide, an E3 ligase ligand-linker, and a 3-unit PEG linker. This conjugate is specifically designed for use in PROTAC technology. | |||
T18633 |
PROTAC MDM2 Degrader-3
|
Others | Others |
PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1]. | |||
T39494 |
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH,(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH |
||
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, also known as VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, is a conjugate compound comprising a ligand-linker that targets E3 ligase and, on one end, features a VHL ligand. It is employed in PROTAC technology applications. | |||
T39215 |
Thalidomide-O-amido-C3-PEG3-C1-NH2
Thalidomide-O-amido-C3-PEG3-C1-NH2 |
||
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized conjugate compound that serves as an E3 ligase ligand-linker. It features a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology. | |||
T17917 |
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
E3 Ligase Ligand-Linker Conjugates 23 TFA,Cereblon Ligand-Linker Conjugates 12 TFA |
Others | Others |
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications. | |||
T17902 |
Nutlin-C1-amido-PEG4-C2-N3
E3 ligase Ligand-Linker Conjugates 48,MDM2 Ligand-Linker Conjugates 1 |
Others | Others |
Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. This compound is specifically designed for utilization in PROTAC technology. | |||
T41198 |
BRD PHOTAC-I-3
|
||
BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+)-JQ1. Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark. | |||
T18820 |
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
|
Others | Others |
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1]. | |||
T18068 |
Lenalidomide-PEG3-iodine
|
Others | Others |
Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1]. | |||
T39806 |
Pomalidomide 4'-PEG3-azide
Pomalidomide 4'-PEG3-azide |
||
Pomalidomide 4'-PEG3-azide is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound, Pomalidomide 4'-PEG3-azide, is utilized in the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3, developed through the PROTAC strategy, is an effective degrader of PARP1, derived from Rucaparib. |