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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0054 |
Disulfiram
双硫伦,Tetraethylthiuram disulfide,双硫仑,NSC 190940,TETD |
Dehydrogenase; Interleukin; Pyroptosis | Apoptosis; Immunology/Inflammation; Metabolism |
Disulfiram (TETD) 是一种乙醛脱氢酶 ALDH 的抑制剂,抑制 hALDH1 和 hALDH2 (IC50=0.15/1.45 μM),具有特异性。Disulfiram 对酒精产生急性敏感性,还可以抑制 GSDMD 孔形成。 | |||
T61214 |
EWP 815
|
Phosphatase; Hydroxylase | Metabolism |
EWP 815是一种二硫仑类似物,是 Ins(1,4) P 2磷酸酶、Ins(1,4,5) P 3 5-磷酸酶和多巴胺β-羟化酶活性的强效抑制剂[1] [2]。 | |||
T35543 |
Methyl Diethyldithiocarbamate
|
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Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg. 1.Hart, B.W., Yourick, J.J., and... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2252 |
Syrosingopine
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Syrosingopine 是 MCT1和 MCT4双重抑制剂,对 MCT4 的效力高 60 倍,可防止乳酸和 H+ 流出。它是可口服抗高血压药物,联合二甲双胍具有研究癌症疾病的潜力。 | |||
T4876 |
2-(1H-Indol-3-yl)ethan-1-ol
Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇 |
Others; Endogenous Metabolite | Metabolism; Others |
2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) 是在双硫仑治疗后在肝脏中形成的代谢物,可诱导人类睡眠。它也是酒精发酵的二次产物。 |