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Cat. No. Product Name Target Signaling Pathways
T60445 Desipramine

Desipramine 是一种具有抗抑郁活性的三环类化合物。Desipramine 可抑制中枢神经系统的去甲肾上腺素再摄取受体,减少睡眠相关的腮舌肌活性丧失,可用于改善咽塌陷的研究。
T0991 Desipramine hydrochloride

NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020

Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor GPCR/G Protein; Neuroscience
Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药,可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。
T15773 Lofepramine

Gamanil,洛非帕明,Amplit,Leo 640,Lopramine

5-HT Receptor; Norepinephrine GPCR/G Protein; Neuroscience
Lofepramine (Leo 640) 是一种有效的三环抗抑郁药,广泛地代谢为 Desipramine。它能够抑制摄取促进去甲肾上腺素能神经传递,以及抑制神经元摄取 5-羟色胺和色氨酸吡咯酶,增强 5-羟色胺能神经传递,进而发挥其抗抑郁作用。它还具有显著的抗焦虑效果。
T69620 Demexiptiline

Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.
T36521 Alaproclate (hydrochloride)

Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio...

化合物

Desipramine
Cat.No: T60445
Synonym:
Target:
Desipramine hydrochloride
Cat.No: T0991
Synonym: NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020
Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor
Lofepramine
Cat.No: T15773
Synonym: Gamanil,洛非帕明,Amplit,Leo 640,Lopramine
Target: 5-HT Receptor, Norepinephrine
Demexiptiline
Cat.No: T69620
Synonym:
Target:
Alaproclate (hydrochloride)
Cat.No: T36521
Synonym:
Target:
TargetMol Loading
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