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Search Results for " depsipeptide "

14

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6006	Romidepsin FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Romidepsin (FR 901228) 是一种 HDAC 抑制剂，抑制 HDAC1/2/4/6 (IC50=36/47/510/1400 nM)。Romidepsin 具有抗肿瘤活性，可以用于治疗外周 T 细胞淋巴瘤和皮肤 T 细胞淋巴瘤。
T26175	Salinamide A
	Salinamide A is an effective anti-inflammatory bicyclic depsipeptide.
T28943	Telomycin A-128,A 128,A128,NSC 235069,Antibiotic 128
	elomycin is a cyclic depsipeptide antibiotic with activity against Gram-positive bacteria.
T34717	Stevastelin B3 NK374186B3,NK 374186B3,Antibiotic NK 374186B3,NK-374186B3
	Stevastelin B3 is a depsipeptide isolated from Penicillium.
T25326	Didemnin A NSC325319,NSC-325319,NSC 325319,Didemnins
	Didemnin A is an antiviral and antitumor depsipeptide from Carribean tunicate.
T76000	Aurantimycin A
	Aurantimycin A (Adipogen)是一种缩肽类抗生素，具有针对革兰氏阳性菌的高度活性。同时，它也是LieAB转运蛋白的底物。
T16997	Tasidotin hydrochloride ILX651	Microtubule Associated	Cytoskeletal Signaling
	Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and microtubule dynamics.
T36096	Thiocoraline
	Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA sy...
T26456	A 83586C A83586C,A-83586C
	A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating o
T15158	Dolastatin 15 DLS 15	Others	Others
	Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m
T36181	Quinaldopeptin
	Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).
T82479	Elisidepsin PM02734
	Elisidepsin (PM02734) 为环状缩肽类抗肿瘤活性化合物，能够抑制癌细胞的增殖，并在非小细胞肺癌（NSCLC）等癌症研究中有应用。
T36598	Enopeptin A
	Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain. It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 μg/ml), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs = 200 μg/ml); however, it is not inhibitory to fungi.
T76506	Coibamide A
	Coibamide A 是一种 N-甲基稳定的细胞毒性缩酚肽，具有强大的抗增殖活性。Coibamide A 通过mTOR 独立机制诱导自噬体积累。Coibamide A 诱导细胞凋亡。Coibamide A 抑制VEGFA/VEGFR2表达并抑制胶质母细胞瘤异种移植物中的肿瘤生长。

化合物

Cat.No: T6006

Synonym: FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176

Target: Apoptosis, HDAC

Cat.No: T26175

Cat.No: T28943

Synonym: A-128,A 128,A128,NSC 235069,Antibiotic 128

Cat.No: T34717

Synonym: NK374186B3,NK 374186B3,Antibiotic NK 374186B3,NK-374186B3

Cat.No: T25326

Synonym: NSC325319,NSC-325319,NSC 325319,Didemnins

Cat.No: T76000

Tasidotin hydrochloride

Cat.No: T16997

Synonym: ILX651

Target: Microtubule Associated

Cat.No: T36096

Cat.No: T26456

Synonym: A83586C,A-83586C

Cat.No: T15158

Synonym: DLS 15

Target: Others

Cat.No: T36181

Cat.No: T82479

Synonym: PM02734

Cat.No: T36598

Cat.No: T76506

Cat. No.	Product Name	Target	Signaling Pathways
T25327	Didemnin B NSC 325319,NSC325319,膜海鞘素B,NSC-325319,Didemnin-B	Antiviral	Immunology/Inflammation
	Didemnin B (Didemnin-B) 是一种从海洋金枪鱼 Tridemnin cyanophorum 中提取的脱脂肽，具有抗病毒和抗肿瘤活性。
TP1072	Valinomycin 缬氨霉素,NSC 122023	Apoptosis; PTEN; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Valinomycin (NSC-122023) 是钾离子选择性运输载体，是一种环状缩酚肽类抗生素。它通过影响生物膜抑制淋巴细胞的扩增，能诱导 CHO 细胞凋亡，也可诱导 PINK1 激活，促进 Parkin 在 Ser65 位点磷酸化。
T68351	Homodestcardin
	Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.

天然产物

Cat.No: T25327

Synonym: NSC 325319,NSC325319,膜海鞘素B,NSC-325319,Didemnin-B

Target: Antiviral

Cat.No: TP1072

Synonym: 缬氨霉素,NSC 122023

Target: Apoptosis, PTEN, Antibacterial, Antibiotic, Autophagy

Cat.No: T68351

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