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Search Results for " daunorubicin "

17

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25291	Daunosamnyl-daunorubicin
	Daunosamnyl-daunorubicin is used as an antibody conjugate.
T29825	Alanylleucyl-daunorubicin
	Alanylleucyl-daunorubicin is a biochemical.
T73700	Daunorubicin citrate
	Daunorubicin citrate（Daunomycin citrate）作为一种拓扑异构酶 II（topoisomerase II）抑制剂，展现出有效的抗肿瘤活性，通过抑制 DNA 和 RNA 合成（DNA and RNA synthesis）发挥作用。作为一种细胞毒性药物，Daunorubicin citrate 能够抑制癌细胞活性，并诱导细胞凋亡（apoptosis）和坏死（necrosis），属于蒽环类抗生素范畴。该化合物广泛应用于包括白血病、非霍奇金淋巴瘤、尤文氏肉瘤、维尔姆斯氏瘤在内的多种癌症和感染研究领域。
T72467	5-Iminodaunorubicin 5-亚氨基柔红霉素
	5-Iminodaunorubicin 是一种醌改性蒽环类药物，具有抗肿瘤活性。5-Iminodaunorubicin 在癌细胞中可诱导 DNA 链断裂。
T18317	MCC-Modified Daunorubicinol	Others	Others
	Daunorubicinol, a potent antitumor drug-linker conjugate for antibody-drug conjugate (ADC) applications, utilizes Aur0101 (DNA Topoisomerase II inhibitor) connected through the ADC linker[1].
T31209	Daunorubicinol Duborimycin,Antibiotic 20-798RP
	Daunorubicinol is the main metabolite of daunomycin.
T72115	5-Iminodaunorubicin hydrochloride 盐酸5-亚氨基柔红霉素
	5-Iminodaunorubicin hydrochloride 是一种醌改性蒽环类药物，具有抗肿瘤活性。5-Iminodaunorubicin hydrochloride 在癌细胞中可诱导DNA 链断裂。
T15054	Daun02	Topoisomerase	DNA Damage/DNA Repair
	Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T31468	Dihydrodaunomycin HCl Dihydrodaunomycin hydrochloride,Antibiotic RP 20798,RP20798,RP-20798,RP 20798
	Dihydrodaunomycin HCl is a metabolite of Daunorubicin.
T68948	Detorubicin HCl
	Detorubicin is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.
T26161	Ruboxyl Ruboxyl hydrochloride
	Ruboxyl, a nitroxylated analog of daunorubicin, is an anthracycline antibiotic.
T68909	Detorubicin Free Base
	Detorubicin Free Base is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.
T31088	CPX-351 Cytarabine/daunonubicin,Vyxeos,CPX 351,Daunonubicin/cytarabine
	CPX-351 is a Liposomal-encapsulated combination of daunorubicin and cytarabine for the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs).
T69130	Zorubicin Rubidazon ; Rubidazone,Rubidazone,Rubidazon
	Zorubicin (Rubidazon) 是Daunorubicin 的衍生物。Zorubicin 与拓扑异构酶 II 相互作用，抑制DNA 聚合酶。Zorubicin 可用于急性白血病和肉瘤的研究。
T37851	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging...
T37068	NR-160
	NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
T35696	Olomoucine II
	Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM for all) but does inhibit ERK2 (IC50= 32 μM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 μM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 μM, respectively...

化合物

Daunosamnyl-daunorubicin

Cat.No: T25291

Alanylleucyl-daunorubicin

Cat.No: T29825

Daunorubicin citrate

Cat.No: T73700

5-Iminodaunorubicin

Cat.No: T72467

Synonym: 5-亚氨基柔红霉素

MCC-Modified Daunorubicinol

Cat.No: T18317

Target: Others

Daunorubicinol

Cat.No: T31209

Synonym: Duborimycin,Antibiotic 20-798RP

5-Iminodaunorubicin hydrochloride

Cat.No: T72115

Synonym: 盐酸5-亚氨基柔红霉素

Cat.No: T15054

Target: Topoisomerase

Dihydrodaunomycin HCl

Cat.No: T31468

Synonym: Dihydrodaunomycin hydrochloride,Antibiotic RP 20798,RP20798,RP-20798,RP 20798

Detorubicin HCl

Cat.No: T68948

Cat.No: T26161

Synonym: Ruboxyl hydrochloride

Detorubicin Free Base

Cat.No: T68909

Cat.No: T31088

Synonym: Cytarabine/daunonubicin,Vyxeos,CPX 351,Daunonubicin/cytarabine

Cat.No: T69130

Synonym: Rubidazon ; Rubidazone,Rubidazone,Rubidazon

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Cat.No: T37851

Cat.No: T37068

Cat.No: T35696

Cat. No.	Product Name	Target	Signaling Pathways
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物，可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
TN2496	1,4-Anthraquinone	Others	Others
	1,4-Anthraquinone 是一种抗癌药物，在体外与柔红霉素相同纳摩尔范围内阻断核苷转运、抑制大分子合成、诱导 DNA 片段化并降低 L1210 白血病细胞的生长和活力。它被提议为一种用于高效液相色谱 (HPLC) 测定药物制剂中 N-乙酰半胱氨酸 (NAC) 和卡托普利 (CAP) 的新型柱前试剂。

天然产物

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

1,4-Anthraquinone

Cat.No: TN2496

Target: Others

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