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Cat. No.	Product Name	Target	Signaling Pathways
T13017	STL127705 Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白抑制剂，抑制 Ku70/80-DNA 相互作用，IC50 为 3.5 μM。它抑制 Ku 依赖性 DNA-PKCS 激酶的激活，IC50 为 2.5 μM。
T2693	AG1024 Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	AG1024 (Tyrphostin) 是一种可逆的，竞争性和选择性的胰岛素样生长因子-1 受体抑制剂，IC50为 7 μM。它抑制胰岛素受体的磷酸化，IC50值为 57 μM。它诱导细胞凋亡并具有抗癌活性。
T61857	DNA-PK-IN-4
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly impairs tumor DNA repair mechanisms and triggers apoptosis in cells. With its potential application in cancer research, DNA-PK-IN-4 holds promise for further investigation [1].
T61633	DNA-PK-IN-2
	DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications in cancer research, DNA-PK-IN-2 demonstrates promise as a valuable tool for studying cancer diseases [1].
T61370	DNA-PK-IN-6
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 amplifies the responsiveness of tumor tissues to radiotherapy, overcomes the challenge of drug resistance, and augments its inhibitory impact on a diverse range of solid and hematological tumors[1].
T62191	DNA-PK-IN-5
	DNA-PK-IN-5 是一种 DNA-PK 的有效抑制剂。DNA-PK-IN-5 能够抑制 DNA-PKcs 活性，明显降低肿瘤 DNA 修复，并诱导细胞凋亡。DNA-PK-IN-5 能够提高肿瘤组织对放疗的敏感性，克服耐药问题，提高对多种实体瘤和血液肿瘤的抑制效果。
T64204	NU5455
	NU5455 是一种选择性的、有效的、口服具有活力的 DNA-PKcs 抑制剂。NU5455 能够提高肝肿瘤异种移植物中局部释放的多柔比星的效果，且不引起任何不良反应。NU5455 能够提高肠胃外给药的拓扑异构酶抑制剂的功效和毒性。
T62648	DNA-PK-IN-1
	DNA-PK-IN-1 是一种 DNA-PK 的有效抑制剂。DNA 依赖性蛋白激酶 (DNA-PK) 是一种由 Ku70/Ku80 异二聚体和 DNA 依赖性蛋白激酶催化亚基 (DNA-PKcs) 组成的 DNA-PK 酶复合物。DNA-PK-IN-1 具有潜力进行癌症疾病的研究。