首页工具

登录

搜索结果

Search Results for " dm4 "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T15141	DM4 Ravtansine,美登素 DM4	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	DM4 (Ravtansine)可用于制备抗体药物偶联物，是抗微管蛋白剂。它抑制细胞分裂。
T38682	Lys-Nε-SPDB-DM4 Lys-Nε-SPDB-DM4
	Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC).
T17834	DM4-SPDP	Others	Others
	DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].
T18701	SPDB-DM4	Others	Others
	SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.
T11059	DM4-SMe	Others	Others
	DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SM
T13766	Maytansinoid DM4	Others	Others
	Maytansinoid DM4, a thiol-containing maytansine derivative, is a highly potent cytotoxic moiety utilized in ADC applications.
T17833	DM4-SMCC	Others	Others
	DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1].
T18702	DBA-DM4	Others	Others
	DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1].
T18730	sulfo-SPDB-DM4	Others	Others
	Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.
T18731	Sulfo-PDBA-DM4	Others	Others
	Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cytotoxic potential through Sulfo-PDBA's targeted delivery mechanism.
T77907	Tusamitamab ravtansine HuMAb2-3-SPDB-DM4,SAR-408701
	Tusamitamab ravtansine (SAR-408701) 是一款针对CEACAM5的人源化单克隆抗体与DM4细胞毒性药物经活性分子连接而成的抗体-药物偶联物(ADC)，专门靶向CEACAM5表达的肿瘤细胞。
T77872	S-Me-DM4
	S-Me-DM4是DM4在胞内酶作用下发生S-甲基化反应形成的代谢产物。DM4本身是一种具有强细胞毒性的含硫醇类微管解聚剂，并可作为ADC Cytotoxin分子应用。
T4214	KDM4D-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM4D-IN-1 是一种 KDM4D 抑制剂，IC50为 0.41±0.03 μM。
T60654	KDM4C-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM4C-IN-1 是一种具有选择性和高效性的KDM4C 抑制剂（IC50：8 nM），具有潜在的抗癌活性。KDM4C-IN-1 抑制 HepG2 和 A549 细胞的生长，可用于研究白血病。
T27721	KDM4C-IN-35 KDM4C IN 35,KDM4CIN35
	KDM4C-IN-35 is a novel and selective KDM4C inhibitor.
T11749	KDM4-IN-2	Glucokinase	Metabolism
	KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T60354	KDM4-IN-4
	KDM4-IN-4 (compound 47) 是一种有效的组蛋白赖氨酸特异性脱甲基酶 4 (KDM4)抑制剂，与 KDM4A-Tudor 结构域约有 80 μM 的亲和力。KDM4-IN-4 可以抑制细胞内 H3K4Me3 与 Tudor 结构域的结合，EC50为 105 μM。KDM4-IN-4 可用于抗癌研究。
T27722	KDM4-IN-I
	KDM4-IN-I is a novel inhibitor of KDM4.
T25142	BDM44768 BDM 44768,BDM-44768
	BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.
T60593	KDM4-IN-3
	KDM4-IN-3 是赖氨酸脱甲基酶4(KDM4)的抑制剂。KDM4-IN-3 具有细胞渗透性，可在低微摩尔浓度下杀死前列腺癌细胞。
T4346	SPDB	Others	Others
	SPDB 是一种可降解的 ADC 连接剂，可用于合成抗体偶联药物。它是一个与 DM4 偶联物相连的小片段，利用二硫键与抗体偶联。
T40162	Acid-C3-SSPy Acid-C3-SSPy
	Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 , a drug-linker conjugate for ADC.
T76940	Cantuzumab ravtansine
	Cantuzumab ravtansine (IMGN242; huC242-DM4) 是一种 ADC，由一种人源化单克隆抗体 huC242，通过二硫键与 DM4 (DM4) 共价连接。Cantuzumab ravtansine 对一系列 CanAg 阳性人肿瘤异种移植物具有广泛的抗肿瘤功效。
T77825	Mirvetuximab soravtansine IMGN853
	Mirvetuximab soravtansine (IMGN853)是一种抗体药物偶联物（ADC），包含与人源化单克隆抗体M9346A共价连接的细胞毒素maytansoid DM4。该药物特异性地结合于叶酸受体1 (FOLR1)，显示出抑制细胞生长和增强DNA损伤的抗增殖效果。

化合物

Cat.No: T15141

Synonym: Ravtansine,美登素 DM4

Target: Others, Microtubule Associated

Lys-Nε-SPDB-DM4

Cat.No: T38682

Synonym: Lys-Nε-SPDB-DM4

Cat.No: T17834

Target: Others

Cat.No: T18701

Target: Others

Cat.No: T11059

Target: Others

Maytansinoid DM4

Cat.No: T13766

Target: Others

Cat.No: T17833

Target: Others

Cat.No: T18702

Target: Others

Cat.No: T18730

Target: Others

Cat.No: T18731

Target: Others

Tusamitamab ravtansine

Cat.No: T77907

Synonym: HuMAb2-3-SPDB-DM4,SAR-408701

Cat.No: T77872

Cat.No: T4214

Target: Histone Demethylase

Cat.No: T60654

Target: Histone Demethylase

Cat.No: T27721

Synonym: KDM4C IN 35,KDM4CIN35

Cat.No: T11749

Target: Glucokinase

Cat.No: T60354

Cat.No: T27722

Cat.No: T25142

Synonym: BDM 44768,BDM-44768

Cat.No: T60593

Cat.No: T4346

Target: Others

Cat.No: T40162

Synonym: Acid-C3-SSPy

Cantuzumab ravtansine

Cat.No: T76940

Mirvetuximab soravtansine

Cat.No: T77825

Synonym: IMGN853

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼