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Cat. No.	Product Name	Target	Signaling Pathways
T21408	DM1-SMe DM1-SSMe	Microtubule Associated	Cytoskeletal Signaling
	DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍，在一组人类肿瘤细胞系中，DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T16899	SMCC-DM1 DM1-SMCC	Others	Others
	SMCC-DM1 (DM1-SMCC) 是一种药物-接头偶联物，由有效的微管破坏剂 DM1 和接头 SMCC 组成，用于制备抗体药物偶联物。
T11917	Lys-SMCC-DM1 Lys-Nε-MCC-DM1	Microtubule Associated	Cytoskeletal Signaling
	DM1 是一种微管蛋白抑制剂。 Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是 DM1 的活性代谢物。
T1992	Mertansine DM1,Maytansinoid DM1	Microtubule Associated	Cytoskeletal Signaling
	Mertansine (DM1) 是一种微管蛋白抑制剂，也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上，形成抗体偶联药物。
T24007	DM1-MCC MCC-DM1	Others	Others
	DM1-MCC (MCC-DM1) 是一种具有 MCC 接头的抗癌药物 DM1。
T38493	MCC-DM1 MCC-DM1
	MCC-DM1 is a drug-Linker Conjugates for ADC such ad Anti-CD22-MCC-DM1.
T38788	MC-DM1 MC-DM1
	MC-DM1 is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody drug conjugate (ADC).
T18718	SPP-DM1	Others	Others
	SPP-DM1, a drug-linker conjugate for antibody-drug conjugates (ADC), demonstrates potent antitumor activity. It comprises DM1 (a potent microtubule-disrupting agent) connected through the ADC linker SPP[1].
T12805	S-methyl DM1	Microtubule Associated	Cytoskeletal Signaling
	S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
T17832	DM1-PEG4-DBCO	Others	Others
	DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for the development of antibody-drug conjugates (ADCs). This conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1’s capabilities as an antibody-conjugatable maytansinoid.
T18305	Mal-VC-PAB-DM1	Others	Others
	Mal-VC-PAB-DM1, a drug-linker conjugate for antibody-drug conjugates (ADCs), exhibits potent antitumor activity. It incorporates DM1, a potent microtubule-disrupting agent, connected through the ADC linker Mal-VC-PAB [1].
T17793	DBCO-PEG4-Ahx-DM1	Others	Others
	DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that combines the microtubulin inhibitor DM1 (mertansine), which is an antibody-conjugatable maytansinoid designed to reduce systemic toxicity and improve tumor-specific delivery, with the linker DBCO-PEG4-Ahx, for the development of antibody drug conjugates (ADCs).
T18678	SC-VC-PAB-DM1	Others	Others
	SC-VC-PAB-DM1 is a drug-linker conjugate utilized in Antibody-Drug Conjugates (ADC), featuring DM1 (Mertansine, a tubulin inhibitor) linked through the SC-VC-PAB[1] ADC linker to deliver potent antitumor activity.
T77848	vc-PABC-DM1
	vc-PABC-DM1用于合成基于二硫键的ADC分子，且可探索其血清稳定性。
T5541	PDM11 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11	AhR	Immunology/Inflammation; Metabolism
	PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) 是抗氧化剂白藜芦醇的衍生物。它在白藜芦醇活性测定中不活跃。它对辐射分解产生的羟基自由基引发的亚油酸胶束氧化没有明显的保护作用。
T28235	OMDM169 OMDM 169,OMDM-169
	OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM<IC(50)<0.41 microM towards 2-AG hydrolysing activities in
T25141	BDM14471 BDM-14471,BDM 14471
	BDM14471 is a selective inhibitor of hydroxamate PfAM1.
T62405	KDM1/CDK1-IN-1
	KDM1/CDK1-IN-1 (compound 4) 是一种有效的 KDM1 (IC50: 0.096 μM) 和 CDK1 (IC50: 0.078 μM) 抑制剂。KDM1/CDK1-IN-1 能够将 HOP-92 细胞的细胞周期阻滞在 G2/M 期，并诱导其凋亡 (apoptosis)。KDM1/CDK1-IN-1 对 CCRF-CEM 细胞 (IC50: 16.34 μM)、HOP-92 细胞 (IC50: 3.45 μM) 和 Hep-G2 细胞 (IC50: 7.79 μM) 具有较强的细胞毒性。
T80721	Zndm19
	Zndm19为New Delhi Metallo-β-lactamase-1 (NDM-1)的抑制剂，适用于抗药性细菌感染研究。
T68612	DM175
	DM175 is a novel partial FXR agonist, causing specific modulatory effects on FXR activity that clearly differ from classical FXR agonists.
T24647	PKR-IN-C51 PKRINC51,PKR IN C51,PKR-inhibitor-C51,PKR inhibitor C51
	PKR-IN-C51 is an inhibitor of protein kinase R. It acts by correcting the aberrant splicing of MBNL1-dependent pre-mRNAs in DM1 cells without affecting the splicing pattern in normal non-DM1 cells.
T76939	Cantuzumab mertansine
	Cantuzumab mertansine (SB-408075; huC242-DM1) 是一种ADC，是强效美登素衍生物 (DM1) 和针对 CanAg 的人源化单克隆抗体 (huC242) 的免疫偶联物。Cantuzumab mertansine 对结肠癌细胞具有细胞毒性，并且对一系列 CanAg 阳性人肿瘤异种移植物具有广泛的抗肿瘤活性。
T36647	Trastuzumab emtansine	Others	Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine. This compound is utilized in the investigation of advanced breast cancer[1][2].
T77821	MCC
	MCC 为一种用于ADC合成的不可降解连接子，例如用于制得MCC-DM1。
T18702	DBA-DM4	Others	Others
	DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1].
TP1804	PEN-221
	PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM. PEN-221 is a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate.

化合物

Cat.No: T21408

Synonym: DM1-SSMe

Target: Microtubule Associated

Cat.No: T16899

Synonym: DM1-SMCC

Target: Others

Cat.No: T11917

Synonym: Lys-Nε-MCC-DM1

Target: Microtubule Associated

Cat.No: T1992

Synonym: DM1,Maytansinoid DM1

Target: Microtubule Associated

Cat.No: T24007

Synonym: MCC-DM1

Target: Others

Cat.No: T38493

Synonym: MCC-DM1

Cat.No: T38788

Synonym: MC-DM1

Cat.No: T18718

Target: Others

Cat.No: T12805

Target: Microtubule Associated

Cat.No: T17832

Target: Others

Cat.No: T18305

Target: Others

DBCO-PEG4-Ahx-DM1

Cat.No: T17793

Target: Others

Cat.No: T18678

Target: Others

Cat.No: T77848

Cat.No: T5541

Synonym: 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11

Target: AhR

Cat.No: T28235

Synonym: OMDM 169,OMDM-169

Cat.No: T25141

Synonym: BDM-14471,BDM 14471

Cat.No: T62405

Cat.No: T80721

Cat.No: T68612

Cat.No: T24647

Synonym: PKRINC51,PKR IN C51,PKR-inhibitor-C51,PKR inhibitor C51

Cantuzumab mertansine

Cat.No: T76939

Trastuzumab emtansine

Cat.No: T36647

Target: Others

Cat.No: T77821

Cat.No: T18702

Target: Others

Cat.No: TP1804

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