Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6730 |
WAY-600
6-(1H-吲哚-5-基)-4-(4-吗啉基)-1-[1-(3-吡啶基甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶,WAY600 |
VEGFR; PI3K; Src; mTOR | Angiogenesis; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
WAY-600 是一种有效的,选择性的,ATP 竞争型的mTOR 抑制剂,抑制重组 mTOR 酶,其 IC50=9 nM。它能够阻断 mTOR 复合物 1/2 (mTORC1/2) 组装和激活。 | |||
T24083 |
Gallopamil, (-)-
(-)-Methoxyverapamil,(S)-Gallopamil,(-)-Gallopamil,(-)-D 600 |
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Gallopamil, (-)- is an L-type calcium channel blocker. It is used in the treatment of abnormal heart rhythms. | |||
TP1893L1 |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base)
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Melanocortin Receptor | GPCR/G Protein; Neuroscience |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base) 是选择性黑皮质素 3 (MC3) 受体激动剂(对人 MC3、MC5 和 MC4 受体的 IC50 值分别为 6.7、340 和 600 nM)。显示有抗炎功效。 | |||
TP1893 |
[D-Trp8]-γ-MSH
|
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[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). [D-Trp8]-γ-MSH displays anti-inflammatory efficacy. | |||
T75854 |
[D-Trp8]-γ-MSH TFA
|
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[D-Trp8]-γ-MSH TFA 是一种有效的、选择性的黑皮质素3 (MC3)受体激动剂,在 CHO 细胞中,抑制 hMC3,hMC4和 hMC5的 IC50值分别为 6.7 nM,600 nM 和 340 nM。[D-Trp8]-γ-MSH TFA 显示出对多种炎症性疾病(如类风湿关节炎和结肠炎)的保护作用。 | |||
T36418 |
O-Desmethyl-N-deschlorobenzoyl Indomethacin
|
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O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ... | |||
T40439 |
Sarizotan
EMD 128130 |
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Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors. It has shown potent activity with IC 50 values of 6.5 nM for rat 5-HT 1A , 0.1 nM for human 5-HT 1A , 15.1 nM for rat D 2 , 17 nM for human D 2 , 6.8 nM for human D 3 , and 2.4 nM for human D 4.2 . |