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Search Results for " cyclosporin a "

14

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1387	Cyclosporin A-Derivative 2
	Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin.
TP1845	Cyclosporin A-Derivative 1
	Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A.
TP1405	Cyclosporin A-Derivative 1 Free base
	Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A.
T19848	Cyclosporin B 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2
	Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also
T34999	UNIL-088 UNIL 088
	UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological c
T76220	Cyclosporin A-Derivative 3
	Cyclosporin A-Derivative 3 是 Cyclosporin A 的衍生物，具有钙调神经磷酸酶抑制作用。
T64488	6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin A
	6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64488。
T21493	Cyclosporin H	Others	Others
	Cyclosporin H 是一种 FPR-1(甲酰肽受体 1) 的选择性强效抑制剂。它缺乏 Cyclosporin A 具有的免疫抑制活性。它是一种病毒转导增强剂，可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强 10 倍。它与雷帕霉素或前列腺素 E2 联合使用时表现出累加效应。
T25281	Cyclopeptolide 1 SDZ 90-215,Cyclopeptolide-1
	Cyclopeptolide 1 is a novel antifungal cyclopeptolide. Cyclopeptolide 1 is similar to cyclosporin A that consists of nine S-amino acids and R-lactic acid.
TP1665	Cyclosporin D
	Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
T19785	Isocyclosporin A IsocyclosporinA,Isocyclosporin-A
	Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.
T68594	NFAT:AP-1 inhibitor-10
	NFAT:AP-1 inhibitor-10 is a novel inhibitor of the NFAT:AP-1:DNA interaction on the ARRE-2 element, binding to DNA in a sequence-selective manner and inhibiting the transcription of the Il2 gene and several other cyclosporin A-sensitive cytokine genes important for the effector immune response.
T82222	H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe
	H-D-MeAla-EtVal-Val-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVal-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe 是一种非免疫抑制性的环孢菌素A衍生物，具备研究先天性肌营养不良症潜力[1]。
T26090	Rioprostil TR 4698,TR4698,Rioprostilum,TR-4698
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco

化合物

Cyclosporin A-Derivative 2

Cat.No: TP1387

Cyclosporin A-Derivative 1

Cat.No: TP1845

Cyclosporin A-Derivative 1 Free base

Cat.No: TP1405

Cyclosporin B

Cat.No: T19848

Synonym: 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2

Cat.No: T34999

Synonym: UNIL 088

Cyclosporin A-Derivative 3

Cat.No: T76220

6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin A

Cat.No: T64488

Cyclosporin H

Cat.No: T21493

Target: Others

Cyclopeptolide 1

Cat.No: T25281

Synonym: SDZ 90-215,Cyclopeptolide-1

Cyclosporin D

Cat.No: TP1665

Isocyclosporin A

Cat.No: T19785

Synonym: IsocyclosporinA,Isocyclosporin-A

NFAT:AP-1 inhibitor-10

Cat.No: T68594

H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe

Cat.No: T82222

Cat.No: T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Cat. No.	Product Name	Target	Signaling Pathways
T0945	Cyclosporin A 环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素	Phosphatase; Antibiotic; Complement System	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Cyclosporin A 属于天然产物，是一种真菌的活性代谢产物，一种环状多肽。Cyclosporin A 是一种能与亲环素结合的免疫抑制剂，可以抑制 calcineurin (IC50=7 nM)。
T82636	Cyclosporin U
	Cyclosporin U (SMP0V32C6L)为一种细胞免疫抑制剂，关键用于防止移植器官的排斥反应。
T19971	Cyclosporin C CsC,Cs-C,Cyclosporin-C,环孢菌素 C	Antiviral; Antifungal	Immunology/Inflammation; Microbiology/Virology
	Cyclosporin C (Cs-C) 是一种抗丝状植物病原真菌的真菌代谢物。 Cyclosporin C 具有抗真菌、抗病毒和免疫抑制特性。
T31467	Dihydrocyclosporin A Dihydrocyclosporin-A,二氢环孢菌素A	Others	Others
	Dihydrocyclosporin A (Dihydrocyclosporin-A) 是 cyclosporin A 的密切相关的共同代谢物。它显着抑制前鞭毛体和细胞内无鞭毛体。
TN4761	Phellamurin	P-gp	Membrane transporter/Ion channel; Neuroscience
	Phellamurin 是一种来自黄檗叶的黄酮糖苷，可诱导细胞凋亡，具有抗肿瘤活性。它抑制肠道 P-糖蛋白，还抑制凤蝶的产卵。
TN4749	Pepluanin A	P-gp	Membrane transporter/Ion channel; Neuroscience
	Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated daunomycin transport.

天然产物

Cyclosporin A

Cat.No: T0945

Synonym: 环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素

Target: Phosphatase, Antibiotic, Complement System

Cyclosporin U

Cat.No: T82636

Cyclosporin C

Cat.No: T19971

Synonym: CsC,Cs-C,Cyclosporin-C,环孢菌素 C

Target: Antiviral, Antifungal

Dihydrocyclosporin A

Cat.No: T31467

Synonym: Dihydrocyclosporin-A,二氢环孢菌素A

Target: Others

Cat.No: TN4761

Target: P-gp

Cat.No: TN4749

Target: P-gp

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