store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydrocyclosporin A (Dihydrocyclosporin-A) 是 cyclosporin A 的密切相关的共同代谢物。它显着抑制前鞭毛体和细胞内无鞭毛体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 783 | 现货 | ||
5 mg | ¥ 1,930 | 现货 | ||
10 mg | ¥ 2,790 | 现货 | ||
25 mg | ¥ 4,630 | 现货 | ||
50 mg | ¥ 6,620 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,810 | 现货 |
产品描述 | Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes. |
靶点活性 | Intracellular amastigotes:4.84 μM(48 h,L. donovani), Intracellular amastigotes:5.23 μM(24 h,L. donovani), Promastigotes:12.14(48 h,L. donovani), Promastigotes:21.24 μM(24 h,L. donovani) |
体外活性 | Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).[2]. |
别名 | Dihydrocyclosporin-A, 二氢环孢菌素A |
分子量 | 1204.63 |
分子式 | C62H113N11O12 |
CAS No. | 59865-15-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (49.81 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.8301 mL | 4.1507 mL | 8.3013 mL | 20.7533 mL |
5 mM | 0.166 mL | 0.8301 mL | 1.6603 mL | 4.1507 mL | |
10 mM | 0.083 mL | 0.4151 mL | 0.8301 mL | 2.0753 mL | |
20 mM | 0.0415 mL | 0.2075 mL | 0.4151 mL | 1.0377 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dihydrocyclosporin A 59865-15-5 Others Dihydrocyclosporin-A 二氢环孢菌素A Inhibitor inhibitor inhibit