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9

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36075	Cholic Acid anilide
	Cholic acid anilide is a synthetic bile acid and derivative of cholic acid that inhibits the germination of C. difficile strain R20291 spores in vitro (IC50 = 1.8 μM).1 \|1. Sharma, S.K., Yip, C., Esposito, E.X., et al. The design, synthesis, and characterizations of spore germination inhibitors effective against an epidemic strain of Clostridium difficile. J. Med. Chem. 61(15), 6759-6778 (2018).
T37854	Cholic Acid 7-sulfate
	Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2]
T7294	Aramchol C20-FABAC	Others	Others
	Aramchol (C20-FABAC) 是一种胆酸和花生酸的结合物，能够降低硬脂酰辅酶 A 去饱和酶 1 (SCD1) 的活性。它具有用于非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 的潜能。
T19235	CHAPS	Others	Others
	CHAPS 是一种两性离子洗涤剂，是一种 Cholic acid 的衍生物，可溶解膜蛋白。它用于稳定各种蛋白质-DNA 复合物，并可以保留溶液中蛋白质的生化活性。
T83900	12β-Hydroxyisocholic Acid LCA,Lagocholic Acid
	12β-Hydroxyisocholic acid是一种胆酸，同时也是胆酸的异构体。在酒精性肝损伤的小鼠模型中，12β-Hydroxyisocholic acid的肝脏水平会升高。
T79424	TGR5 agonist 3
	TGR5激动剂3（化合物8）作为一种胆酸衍生物，表现出选择性TGR5激动特性，其EC50值为5μM。
T79425	TGR5 agonist 4
	TGR5激动剂4（化合物19），作为一种胆酸衍生物，具有优越的TGR5选择性，其EC50值为4μM。
T37666	Trihydroxycholestanoic Acid Trihydroxycoprostanic Acid
	Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.2,3 \|1. Keane, M.H., Overmars, H., Wikander, T.M., et al. Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice. Hepatology 45(4), 982-997 ...
T37873	CAP 3
	CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infecte...

化合物

Cholic Acid anilide

Cat.No: T36075

Cholic Acid 7-sulfate

Cat.No: T37854

Cat.No: T7294

Synonym: C20-FABAC

Target: Others

Cat.No: T19235

Target: Others

12β-Hydroxyisocholic Acid

Cat.No: T83900

Synonym: LCA,Lagocholic Acid

Cat.No: T79424

Cat.No: T79425

Trihydroxycholestanoic Acid

Cat.No: T37666

Synonym: Trihydroxycoprostanic Acid

Cat.No: T37873

Cat. No.	Product Name	Target	Signaling Pathways
T2963	Cholic Acid Cholanic acid,胆汁酸,Cholate,Colalin	Endogenous Metabolite	Metabolism
	Cholic Acid (Cholate) 是肝脏产生的主要胆汁酸，与牛磺酸或甘氨酸缀合，有助于脂肪吸收和胆固醇排泄。
T4537	Cholic acid sodium 胆酸钠,[胆酸钠],SodiumCholate	HIV Protease; Endogenous Metabolite	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Cholic acid sodium (SodiumCholate) 是肝脏中产生的主要胆汁酸，通常与牛磺酸或甘氨酸结合，有助于脂肪吸收和胆固醇排泄。
T2744	Methyl Cholate 胆酸甲酯,Cholic acid methyl ester	Others	Others
	Methyl Cholate (Cholic acid methyl ester) 是胆酸的甲酯形式。其中胆酸是一种由肝脏产生的主要胆汁酸，由胆固醇合成。
T75427	Cholic acid sodium hydrate
	Cholic acid sodium hydrate, 为肝脏主要产生的胆汁酸，常与甘氨酸或牛磺酸结合，促进脂肪吸收及胆固醇排出，具备口服活性。
TN7120	7-keto-deoxycholic acid 7-Keto-3alpha,12alpha-dihydroxycholanic acid	Others	Others
	7-keto-deoxycholic acid 是由乳酸杆菌和双歧杆菌在特定条件下和体外胆酸转化而来的。
T5072	Glycocholic acid hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Glycocholic acid hydrate 是内源性代谢产物的一种。
T0408	Dehydrocholic acid Dehystolin,Felacrinos,去氢胆酸,Sanocholen,Decholin	Others	Others
	Dehydrocholic acid (Dehystolin) 是一种由胆酸氧化生成的胆汁酸，用作胆液排泄增多剂，能够增加胆汁产量，清除增加的胆汁酸负荷。
T1138	Taurocholic acid sodium salt hydrate 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate	Others; Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Others
	Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) 是一种胆汁酸钠盐水合物，作用是参与脂肪的乳化。
T37177	Norcholic Acid
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
T35400	β-Muricholic Acid β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid
	β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]
T73758	Glycolithocholic acid 3-sulfate
	Glycolithocholic acid 3-sulfate (SLCG) 为一种胆汁酸衍生物及甘胆酸的代谢产物，具有抑制HIV-1复制的作用。该化合物在HIV感染和胆囊疾病的研究中有潜在应用价值。

天然产物

Cholic Acid

Cat.No: T2963

Synonym: Cholanic acid,胆汁酸,Cholate,Colalin

Target: Endogenous Metabolite

Cholic acid sodium

Cat.No: T4537

Synonym: 胆酸钠,[胆酸钠],SodiumCholate

Target: HIV Protease, Endogenous Metabolite

Cat.No: T2744

Synonym: 胆酸甲酯,Cholic acid methyl ester

Target: Others

Cholic acid sodium hydrate

Cat.No: T75427

7-keto-deoxycholic acid

Cat.No: TN7120

Synonym: 7-Keto-3alpha,12alpha-dihydroxycholanic acid

Target: Others

Glycocholic acid hydrate

Cat.No: T5072

Target: Others, Endogenous Metabolite

Dehydrocholic acid

Cat.No: T0408

Synonym: Dehystolin,Felacrinos,去氢胆酸,Sanocholen,Decholin

Target: Others

Taurocholic acid sodium salt hydrate

Cat.No: T1138

Synonym: 牛胆酸钠,牛磺胆酸钠水合物,Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate

Target: Others, Potassium Channel, Endogenous Metabolite

Norcholic Acid

Cat.No: T37177

β-Muricholic Acid

Cat.No: T35400

Synonym: β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid

Glycolithocholic acid 3-sulfate

Cat.No: T73758

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