Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7763 |
Thalidomide-4-OH
Cereblon ligand 2,E3 ligase Ligand 2 |
Ligand for E3 Ligase | PROTAC |
Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T15189 |
Thalidomide-O-amido-C4-N3
E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 linker。 | |||
T17325 |
Pomalidomide-PEG4-C-COOH
Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1 |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T7759 |
Thalidomide-O-amido-C4-NH2 TFA
E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T17878 |
Lenalidomide-C4-NH2 hydrochloride
Cereblon ligand 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 32 hydrochloride |
Others | Others |
Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1]. | |||
T17818 |
Thalidomide-O-amido-C4-NH2
E3 Ligase Ligand-Linker Conjugates 19,Cereblon Ligand-Linker Conjugates 6 |
Others | Others |
Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) is a synthesized ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker. It functions as an E3 ligase ligand-linker conjugate and finds applications in the synthesis of PROTACs[1]. | |||
T17907 |
Pomalidomide-amido-C4-amido-C6-NH-Boc
Cereblon Ligand-Linker Conjugates 21,E3 Ligase Ligand-Linker Conjugates 54 |
Others | Others |
Pomalidomide-amido-C4-amido-C6-NH-Boc, a synthesized conjugate, is a ligand-linker incorporating the cereblon ligand based on Pomalidomide and a PROTAC technology linker. | |||
T17906 |
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc
E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20 |
Others | Others |
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate. | |||
T17875 |
Pomalidomide-C2-NH2
Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T7756 |
Pomalidomide-PEG4-Ph-NH2
|
Ligand for E3 Ligase | PROTAC |
Pomalidomide-PEG4-Ph-NH2 是一种合成的 E3 连接酶配体- linker 偶联物,结合了基于 Pomalidomide 的 cereblon 配体和 4 单元 PEG linker。 | |||
T9387 |
Pomalidomide 4'-PEG2-azide
|
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Pomalidomide 4'-PEG2-azide 是由E3 连接酶配体和linker 组成的偶联物,包括基于 Pomalidomide 的 cereblon 配体和linker。 | |||
T40016 |
Thalidomide-NH-CH2-COOH
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T17916 |
Pomalidomide-PEG4-C2-NH2
Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物,用于 PROTAC 技术中。 | |||
T40026 |
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid |
Others | Others |
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。 | |||
T9401 |
Thalidomide-NH-PEG1-NH2 hydrochloride
4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T40030 |
Thalidomide 4'-ether-alkylC2-amine hydrochloride
halidomide-linker 6 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker,是合成的 E3 连接酶配体-linker 偶联物,可应用于 PROTAC 技术。 | |||
T9382 |
Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739。 | |||
T40547 |
Lenalidomide-4-aminomethyl hydrochloride
|
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Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, PROTAC formation can be facilitated. | |||
T39876 |
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride |
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Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride consists of a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker, making it suitable for PROTACs design. | |||
T39894 |
Thalidomide-4-C3-NH2 hydrochloride
Thalidomide-4-C3-NH2 hydrochloride |
||
Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs. | |||
T38457 |
Lenalidomide-4-OH
|
||
Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC. | |||
T77962 |
Thalidomide-4-O-C11-NH2 hydrochloride
|
||
Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体,能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合,进而形成PROTAC分子,如THAL-SNS-032。 | |||
T77917 |
Thalidomide-4-O-C7-NH2 hydrochloride
|
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Thalidomide-4-O-C7-NH2 hydrochloride是一种Thalidomide衍生的CRBN配体,能够招募cereblon蛋白。该化合物能通过linker与目标蛋白配体结合,用于构建PROTAC分子,如THAL-SNS-032。 | |||
T77963 |
Thalidomide-4-O-C12-NH2 hydrochloride
|
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Thalidomide-4-O-C12-NH2 hydrochloride为基于Thalidomide的cereblon配体,能够招募CRBN蛋白。该化合物可利用linker与目标蛋白配体结合,构建PROTAC分子,如THAL-SNS-032。 | |||
T39806 |
Pomalidomide 4'-PEG3-azide
Pomalidomide 4'-PEG3-azide |
||
Pomalidomide 4'-PEG3-azide is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound, Pomalidomide 4'-PEG3-azide, is utilized in the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3, developed through the PROTAC strategy, is an effective degrader of PARP1, derived from Rucaparib. | |||
T77919 |
Thalidomide-4-O-C10-NH2 hydrochloride
|
||
Thalidomide-4-O-C10-NH2 hydrochloride 是一种Thalidomide衍生的cereblon配体,能募集CRBN蛋白。该化合物可利用linker与特定的靶蛋白配体结合,用以构建PROTAC分子,如THAL-SNS-032。 | |||
T77964 |
Thalidomide-4-O-C14-NH2 hydrochloride
|
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Thalidomide-4-O-C14-NH2 hydrochloride是一款衍生于Thalidomide的cereblon配体,能够招募CRBN蛋白。该化合物通过linker可与目标蛋白的配体结合,进而构建PROTAC分子,例如THAL-SNS-032。 | |||
T36262 |
Thalidomide-NH-C5-NH2 hydrochloride
Pomalidomide 4'-alkylC5-amine |
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Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T83953 |
Pomalidomide 4'-PEG5-amine
|
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Pomalidomide 4'-PEG5-amine是一种功能化的cereblon配体,用于PROTAC研究与开发;它结合了一个E3连接酶配体和一个末端带有氨基的PEG5连接体,以便与目标蛋白配体进行共轭。它是专为PROTAC研发设计的一系列功能化工具分子之一。 | |||
T83932 |
Phenyl-glutarimide 4'-piperazine
|
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Phenyl-glutarimide 4'-piperazine是一种具有piperazine功能化的cereblon配体,可用于PROTACDegrader的开发。该化合物可用于开发PG-PROTACs,与使用IMiD(immunomodulatory imide drug)类似物合成的PROTACs相比,展示出改善的水解稳定性和效力。 | |||
T35475 | aTAG 4531 | ||
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genom... | |||
T35474 | aTAG 2139 | ||
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genome... |