Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 482 | 5日内发货 | ||
5 mg | ¥ 789 | 5日内发货 |
产品描述 | Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1]. |
别名 | Cereblon ligand 1 hydrochloride, E3 ligase Ligand-Linker Conjugates 32 hydrochloride |
分子量 | 351.83 |
分子式 | C17H22ClN3O3 |
CAS No. | T17878 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 130 mg/mL (369.50 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8423 mL | 14.2114 mL | 28.4228 mL | 71.057 mL |
5 mM | 0.5685 mL | 2.8423 mL | 5.6846 mL | 14.2114 mL | |
10 mM | 0.2842 mL | 1.4211 mL | 2.8423 mL | 7.1057 mL | |
20 mM | 0.1421 mL | 0.7106 mL | 1.4211 mL | 3.5529 mL | |
50 mM | 0.0568 mL | 0.2842 mL | 0.5685 mL | 1.4211 mL | |
100 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7106 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lenalidomide-C4-NH2 hydrochloride T17878 Others Lenalidomide C4 NH2 hydrochloride Cereblon ligand 1 hydrochloride Lenalidomide-C-4-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 32 hydrochloride Cereblon ligand 1 Hydrochloride LenalidomideC4NH2 hydrochloride Lenalidomide-C4-NH2 Hydrochloride Inhibitor inhibitor inhibit