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Cat. No.	Product Name	Target	Signaling Pathways
T7763	Thalidomide-4-OH Cereblon ligand 2,E3 ligase Ligand 2	Ligand for E3 Ligase	PROTAC
	Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T7755	Thalidomide 4-fluoride E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮	IRAK; Ligand for E3 Ligase	Immunology/Inflammation; NF-κB; PROTAC
	Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。
T15189	Thalidomide-O-amido-C4-N3 E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。
T17325	Pomalidomide-PEG4-C-COOH Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T7759	Thalidomide-O-amido-C4-NH2 TFA E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T17878	Lenalidomide-C4-NH2 hydrochloride Cereblon ligand 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 32 hydrochloride	Others	Others
	Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].
T17818	Thalidomide-O-amido-C4-NH2 E3 Ligase Ligand-Linker Conjugates 19,Cereblon Ligand-Linker Conjugates 6	Others	Others
	Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) is a synthesized ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker. It functions as an E3 ligase ligand-linker conjugate and finds applications in the synthesis of PROTACs[1].
T17907	Pomalidomide-amido-C4-amido-C6-NH-Boc Cereblon Ligand-Linker Conjugates 21,E3 Ligase Ligand-Linker Conjugates 54	Others	Others
	Pomalidomide-amido-C4-amido-C6-NH-Boc, a synthesized conjugate, is a ligand-linker incorporating the cereblon ligand based on Pomalidomide and a PROTAC technology linker.
T17906	Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20	Others	Others
	Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate.
T17875	Pomalidomide-C2-NH2 Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	Others; Ligand for E3 Ligase	Others; PROTAC
	Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。
T7756	Pomalidomide-PEG4-Ph-NH2	Ligand for E3 Ligase	PROTAC
	Pomalidomide-PEG4-Ph-NH2 是一种合成的 E3 连接酶配体- linker 偶联物，结合了基于 Pomalidomide 的 cereblon 配体和 4 单元 PEG linker。
T9387	Pomalidomide 4'-PEG2-azide	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Pomalidomide 4'-PEG2-azide 是由E3 连接酶配体和linker 组成的偶联物，包括基于 Pomalidomide 的 cereblon 配体和linker。
T40016	Thalidomide-NH-CH2-COOH 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine	Ligand for E3 Ligase	PROTAC
	Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T17916	Pomalidomide-PEG4-C2-NH2 Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22	Others; Ligand for E3 Ligase	Others; PROTAC
	Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物，用于 PROTAC 技术中。
T40026	Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid	Others	Others
	Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。
T9401	Thalidomide-NH-PEG1-NH2 hydrochloride 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成。
T40030	Thalidomide 4'-ether-alkylC2-amine hydrochloride halidomide-linker 6	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker，是合成的 E3 连接酶配体-linker 偶联物，可应用于 PROTAC 技术。
T9382	Thalidomide-NH-C2-PEG3-OH H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是 E3 连接酶配体-linker 偶联物，可用于合成 PROTAC BCL-XL 降解剂 XZ739。
T40547	Lenalidomide-4-aminomethyl hydrochloride
	Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, PROTAC formation can be facilitated.
T39876	Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride
	Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride consists of a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker, making it suitable for PROTACs design.
T39894	Thalidomide-4-C3-NH2 hydrochloride Thalidomide-4-C3-NH2 hydrochloride
	Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs.
T38457	Lenalidomide-4-OH
	Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC.
T77962	Thalidomide-4-O-C11-NH2 hydrochloride
	Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体，能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合，进而形成PROTAC分子，如THAL-SNS-032。
T77917	Thalidomide-4-O-C7-NH2 hydrochloride
	Thalidomide-4-O-C7-NH2 hydrochloride是一种Thalidomide衍生的CRBN配体，能够招募cereblon蛋白。该化合物能通过linker与目标蛋白配体结合，用于构建PROTAC分子，如THAL-SNS-032。
T77963	Thalidomide-4-O-C12-NH2 hydrochloride
	Thalidomide-4-O-C12-NH2 hydrochloride为基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物可利用linker与目标蛋白配体结合，构建PROTAC分子，如THAL-SNS-032。
T39806	Pomalidomide 4'-PEG3-azide Pomalidomide 4'-PEG3-azide
	Pomalidomide 4'-PEG3-azide is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound, Pomalidomide 4'-PEG3-azide, is utilized in the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3, developed through the PROTAC strategy, is an effective degrader of PARP1, derived from Rucaparib.
T77919	Thalidomide-4-O-C10-NH2 hydrochloride
	Thalidomide-4-O-C10-NH2 hydrochloride 是一种Thalidomide衍生的cereblon配体，能募集CRBN蛋白。该化合物可利用linker与特定的靶蛋白配体结合，用以构建PROTAC分子，如THAL-SNS-032。
T77964	Thalidomide-4-O-C14-NH2 hydrochloride
	Thalidomide-4-O-C14-NH2 hydrochloride是一款衍生于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物通过linker可与目标蛋白的配体结合，进而构建PROTAC分子，例如THAL-SNS-032。
T36262	Thalidomide-NH-C5-NH2 hydrochloride Pomalidomide 4'-alkylC5-amine
	Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T83953	Pomalidomide 4'-PEG5-amine
	Pomalidomide 4'-PEG5-amine是一种功能化的cereblon配体，用于PROTAC研究与开发；它结合了一个E3连接酶配体和一个末端带有氨基的PEG5连接体，以便与目标蛋白配体进行共轭。它是专为PROTAC研发设计的一系列功能化工具分子之一。
T83932	Phenyl-glutarimide 4'-piperazine
	Phenyl-glutarimide 4'-piperazine是一种具有piperazine功能化的cereblon配体，可用于PROTACDegrader的开发。该化合物可用于开发PG-PROTACs，与使用IMiD（immunomodulatory imide drug）类似物合成的PROTACs相比，展示出改善的水解稳定性和效力。
T35475	aTAG 4531
	Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genom...
T35474	aTAG 2139
	Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genome...

化合物

Thalidomide-4-OH

Cat.No: T7763

Synonym: Cereblon ligand 2,E3 ligase Ligand 2

Target: Ligand for E3 Ligase

Thalidomide 4-fluoride

Cat.No: T7755

Synonym: E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮

Target: IRAK, Ligand for E3 Ligase

Thalidomide-O-amido-C4-N3

Cat.No: T15189

Synonym: E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-C-COOH

Cat.No: T17325

Synonym: Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-C4-NH2 TFA

Cat.No: T7759

Synonym: E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA

Target: E3 Ligase Ligand-Linker Conjugate

Lenalidomide-C4-NH2 hydrochloride

Cat.No: T17878

Synonym: Cereblon ligand 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 32 hydrochloride

Target: Others

Thalidomide-O-amido-C4-NH2

Cat.No: T17818

Synonym: E3 Ligase Ligand-Linker Conjugates 19,Cereblon Ligand-Linker Conjugates 6

Target: Others

Pomalidomide-amido-C4-amido-C6-NH-Boc

Cat.No: T17907

Synonym: Cereblon Ligand-Linker Conjugates 21,E3 Ligase Ligand-Linker Conjugates 54

Target: Others

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc

Cat.No: T17906

Synonym: E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20

Target: Others

Pomalidomide-C2-NH2

Cat.No: T17875

Synonym: Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-Ph-NH2

Cat.No: T7756

Target: Ligand for E3 Ligase

Pomalidomide 4'-PEG2-azide

Cat.No: T9387

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-NH-CH2-COOH

Cat.No: T40016

Synonym: 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

Target: Ligand for E3 Ligase

Pomalidomide-PEG4-C2-NH2

Cat.No: T17916

Synonym: Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22

Target: Others, Ligand for E3 Ligase

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

Cat.No: T40026

Synonym: 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid

Target: Others

Thalidomide-NH-PEG1-NH2 hydrochloride

Cat.No: T9401

Synonym: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide 4'-ether-alkylC2-amine hydrochloride

Cat.No: T40030

Synonym: halidomide-linker 6

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-NH-C2-PEG3-OH

Cat.No: T9382

Synonym: H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-

Target: E3 Ligase Ligand-Linker Conjugate

Lenalidomide-4-aminomethyl hydrochloride

Cat.No: T40547

Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

Cat.No: T39876

Synonym: Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

Thalidomide-4-C3-NH2 hydrochloride

Cat.No: T39894

Synonym: Thalidomide-4-C3-NH2 hydrochloride

Lenalidomide-4-OH

Cat.No: T38457

Thalidomide-4-O-C11-NH2 hydrochloride

Cat.No: T77962

Thalidomide-4-O-C7-NH2 hydrochloride

Cat.No: T77917

Thalidomide-4-O-C12-NH2 hydrochloride

Cat.No: T77963

Pomalidomide 4'-PEG3-azide

Cat.No: T39806

Synonym: Pomalidomide 4'-PEG3-azide

Thalidomide-4-O-C10-NH2 hydrochloride

Cat.No: T77919

Thalidomide-4-O-C14-NH2 hydrochloride

Cat.No: T77964

Thalidomide-NH-C5-NH2 hydrochloride

Cat.No: T36262

Synonym: Pomalidomide 4'-alkylC5-amine

Pomalidomide 4'-PEG5-amine

Cat.No: T83953

Phenyl-glutarimide 4'-piperazine

Cat.No: T83932

Cat.No: T35475

Cat.No: T35474

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