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抑制剂 & 化合物

3

天然产物

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Cat. No. Product Name Target Signaling Pathways
T36197 CAY10747

CAY10747 is an inhibitor of the protein-protein interaction between heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) and a derivative of celastrol .1It decreases protein levels of the Hsp90-Cdc37 complex and the Hsp90-Cdc37 clients phosphorylated Akt and Cdk4 in A549 cells when used at a concentration of 5 μM. CAY10747 inhibits proliferation of A549, MCF-7, HOS, and HepG2 cells (IC50s = 0.41, 0.64, 0.9, and 0.94 μM, respectively) and induces apoptosis in A549 cells. 1.Li, N., Xu,...

化合物

CAY10747
Cat.No: T36197
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S1050 Pristimerin

扁塑藤素,Celastrol methyl ester

NF-κB; Antibacterial Microbiology/Virology; NF-κB
Pristimerin (Celastrol methyl ester) 是一种可逆的单酰基甘油脂肪酶高效抑制剂,IC50值为93 nM。
T3028 Tripterin

Celastrol,Tripterine,雷公藤红素

Apoptosis; Mitophagy; Proteasome; Autophagy Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
Tripterin (Celastrol) 属于天然产物,是一种蛋白酶体抑制剂,抑制 20S 蛋白酶体的胰凝乳蛋白酶样活性 (IC50=2.5 μM)。Tripterin 具有抗炎、抗感染和免疫调节的作用。
T27174 Dihydrocelastrol

DHCE. (-)-Triptohypol C,Triptohypol C

Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co

天然产物

Pristimerin
Cat.No: T4S1050
Synonym: 扁塑藤素,Celastrol methyl ester
Target: NF-κB, Antibacterial
Tripterin
Cat.No: T3028
Synonym: Celastrol,Tripterine,雷公藤红素
Target: Apoptosis, Mitophagy, Proteasome, Autophagy
Dihydrocelastrol
Cat.No: T27174
Synonym: DHCE. (-)-Triptohypol C,Triptohypol C
Target:
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