Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3535 |
ML240
|
p97 | Ubiquitination |
ML240 是一种选择性的 ATP 竞争性 p97 抑制剂,IC50值为 100 nM。 | |||
T1853 |
NMS-873
|
p97 | Ubiquitination |
NMS873 是一种有效的选择性变构 VCP/p97 抑制剂,IC50值为 30 nM。 | |||
T4684 |
ML241 hydrochloride
|
p97 | Ubiquitination |
ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。 | |||
T1969 |
DBEQ
JRF 12 |
Apoptosis; p97; Autophagy | Apoptosis; Autophagy; Ubiquitination |
DBEQ (JRF 12) 是一种选择性的,ATP 竞争性p97抑制剂,对 p97(wt) 和 p97(C522A) 的IC50值分别为 1.5 μM 和 1.6 μM,也可抑制Vps4,IC50值为 11.5 μM。 | |||
T6796 |
CB-5083
CB5083,CB 5083 |
p97 | Ubiquitination |
CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂,IC50为 11 nM。 | |||
T23616 |
ACJI-99C
ACJI 99 C,ACJI-99-C,ACJI99C |
||
ACJI-99C is a cell-permeable irreversible Cdc48/p97 inhibitor. | |||
T40255 |
VCP/p97 inhibitor-1
VCP/p97 inhibitor-1 |
||
VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS). |