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Search Results for " csp "

Targets Recommended: Beta Amyloid Gamma-secretase

7

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2262	Itanapraced CHF5074,CSP-1103	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Itanapraced (CHF5074) 是新型γ-secretase 调节剂，能够降低 Aβ42 (IC50=3.6 nM) 和 Aβ40 (IC50=18.4 nM) 分泌。
T69061	CSP-2503
	CSP-2503 is a 5-HT1A receptor agonist.
T38559	Competence-Stimulating Peptide-2 (CSP-2)
	Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide synthesized by Streptococcus pneumoniae. ComD2, a compatible receptor of CSP-2, exhibits an EC 50 value of 50.7 nM.
T39175	CSP1
	CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent.
T8778	TTK21	Epigenetic Reader Domain	Chromatin/Epigenetic
	TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂，与葡萄糖基碳纳米球结合时，可通过血脑屏障，对成人大脑神经发生和长期记忆功能有益。
T63163	cSPM
	cSPM (Cyclic spermine) 是一种 Aβ42 抑制剂。cSPM 对三种不同肽 Aβ42、胰淀素和胰岛素的聚集具有抑制作用，且能够减少细胞毒性。
T21220	3-Chlorodiphenylamine 3-Cl DPA,3-氯二苯胺,3-Cl-DPA,3 Cl-DPA
	3-Cl-DPA, a cardiac troponin activator, acts by a mechanism distinct from bepridil or TFP.

化合物

Cat.No: T2262

Synonym: CHF5074,CSP-1103

Target: Beta Amyloid, Gamma-secretase

Cat.No: T69061

Competence-Stimulating Peptide-2 (CSP-2)

Cat.No: T38559

Cat.No: T39175

Cat.No: T8778

Target: Epigenetic Reader Domain

Cat.No: T63163

3-Chlorodiphenylamine

Cat.No: T21220

Synonym: 3-Cl DPA,3-氯二苯胺,3-Cl-DPA,3 Cl-DPA

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00817	Granzyme B/GZMB Protein, Human, Recombinant (His) CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,gran...	Human	HEK293 Cells
	Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G...
TMPH-03588	ComC Protein, S. mitis, Recombinant (His & KSI) comC,CSP,Competence-stimulating peptide	Streptococcus mitis	E. coli
	Acts as a pheromone, induces cells to develop competence for genetic transformation. ComC Protein, S. mitis, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 17.3 kDa and the accession number is O33666.
TMPY-00818	Granzyme H/GZMH Protein, Human, Recombinant (His) CTSGL2,CSP-C,CCP-X,granzyme H,CTLA1,CGL-2,GZMH	Human	HEK293 Cells
	Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/...
TMPH-03467	CspA Protein, Salmonella enteritidis, Recombinant (His & Myc) CS7.4,CSP-A,cspA,Cold shock protein Cs...	Salmonella enteritidis	E. coli
	Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'. CspA Protein, Salmonella enteritidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.7 kDa and the accession number is P0A9Y5.
TMPK-01381	CSPG4/MCSP Protein, Cynomolgus, Recombinant (His) MCSPG,CSPG4,MCSP,NG2	Cynomolgus	HEK293 Cells
	The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization.
TMPK-00612	CSPG5 Protein, Mouse, Recombinant (His) MGC44034,Chondroitin sulfate proteoglycan 5,Neuroglycan C,Ca...	Mouse	HEK293 Cells
	CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells.
TMPH-01086	CSPG4 Protein, Human, Recombinant (His & Myc) MCSP,Melanoma chondroitin sulfate proteoglycan,Chon...	Human	HEK293 Cells
	CSPG4 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 73.2 kDa and the accession number is Q6UVK1.
TMPK-00621	CSPG5 Protein, Human, Recombinant (His) CALEB,NGC,MGC44034,Neuroglycan C	Human	HEK293 Cells
	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming. CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.

重组蛋白

Granzyme B/GZMB Protein, Human, Recombinant (His)

Cat.No: TMPY-00817

Species: Human

Expression System: HEK293 Cells

ComC Protein, S. mitis, Recombinant (His & KSI)

Cat.No: TMPH-03588

Species: Streptococcus mitis

Expression System: E. coli

Granzyme H/GZMH Protein, Human, Recombinant (His)

Cat.No: TMPY-00818

Species: Human

Expression System: HEK293 Cells

CspA Protein, Salmonella enteritidis, Recombinant (His & Myc)

Cat.No: TMPH-03467

Species: Salmonella enteritidis

Expression System: E. coli

CSPG4/MCSP Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01381

Species: Cynomolgus

Expression System: HEK293 Cells

CSPG5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00612

Species: Mouse

Expression System: HEK293 Cells

CSPG4 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01086

Species: Human

Expression System: HEK293 Cells

CSPG5 Protein, Human, Recombinant (His)

Cat.No: TMPK-00621

Species: Human

Expression System: HEK293 Cells

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