Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T64066 |
CSF1R-IN-3
|
c-Fms; CSF-1R | Tyrosine Kinase/Adaptors |
CSF1R-IN-3是一种口服有效的 CSF-1R 抑制剂,IC50值为2.1nM。CSF1R-IN-3对结直肠癌细胞具有抗增殖活性。CSF1R-IN-3 通过抑制巨噬细胞的迁移,诱导 M2 型巨噬细胞重新编程为 M1 型巨噬细胞,从而表现出抗肿瘤作用和提高免疫力的作用,展现对结直肠癌细胞的活性。 | |||
T4075 |
Sulfatinib
KDR-IN-1,索凡替尼 |
VEGFR; FGFR; HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Sulfatinib (KDR-IN-1) (HMPL-012) 是一种有效且高度选择性的酪氨酸激酶抑制剂,可抑制VEGFR1/2/3,FGFR1和CSF1R,IC50范围为1 到 24 nM 之间。 | |||
T71400 |
Quizartinib HCl
|
||
Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell pro... |