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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T16522 Phenoxodiol

脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Apoptosis; IAP; Caspase; Topoisomerase; p53 Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
Phenoxodiol (Idronoxil) 是合成genestein 的类似物,激活线粒体caspase 系统,抑制XIAP,使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞,通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II,从而阻止DNA 复制。

化合物

Phenoxodiol
Cat.No: T16522
Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E
Target: Apoptosis, IAP, Caspase, Topoisomerase, p53
Cat. No. Product Name Target Signaling Pathways
T36893 4-oxo Withaferin A

4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian ca...
T35647 4-oxo-27-TBDMS Withaferin A

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of wi...

天然产物

4-oxo Withaferin A
Cat.No: T36893
Synonym:
Target:
4-oxo-27-TBDMS Withaferin A
Cat.No: T35647
Synonym:
Target:
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