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Search Results for " cnx "

Targets Recommended: BTK

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2302	CNX-774 CNX 774	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	CNX-774 是一种选择性的、具有口服活性的、不可逆的 BTK 抑制剂 (IC50<1 nM)。它能够特异性靶向 Btk 的 Cys 481进行共价修饰。
T6008	CNX-2006 CNX 2006,CNX2006	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	CNX-2006 是一种新型的不可逆突变选择性 EGFR 抑制剂，对 EGFRT790M 的IC50值小于 20 nM。
T2256	CNX-1351 1-[4-[[2-(1H-吲唑-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-6-基]甲基]-1-哌嗪基]-6-甲基-5-庚烯-1,4-二酮	PI3K	PI3K/Akt/mTOR signaling
	CNX1351 是有效的、选择性的 PI3Kα 抑制剂，其 IC50=6.8 nM。
T10854	CNX-500	Others	Others
	CNX-500 is a probe consisting of a covalent Btk inhibitor chemically linked to biotin. CNX-500 has inhibitory activity against Btk (IC50: 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase EGFR and upstr
T2369	Rociletinib AVL-301,CNX-419,CO-1686	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Rociletinib (CNX-419) 是一种可口服的EGFR 抑制剂，能够抑制 EGFRL858R/T790M 和 EGFRWT 的活性，IC50值分别为 21.5 nM 和 303.3 nM。
T14993	Rociletinib hydrobromide AVL-301 hydrobromide,CO-1686 (hydrobromide),CNX-419 hydrobromide	Others	Others
	Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).

化合物

CNX-774

Cat.No: T2302

Synonym: CNX 774

Target: BTK

CNX-2006

Cat.No: T6008

Synonym: CNX 2006,CNX2006

Target: EGFR

CNX-1351

Cat.No: T2256

Synonym: 1-[4-[[2-(1H-吲唑-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-6-基]甲基]-1-哌嗪基]-6-甲基-5-庚烯-1,4-二酮

Synonym: AVL-301,CNX-419,CO-1686

Target: EGFR

Rociletinib hydrobromide

Cat.No: T14993

Synonym: AVL-301 hydrobromide,CO-1686 (hydrobromide),CNX-419 hydrobromide

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04809	Calnexin Protein, Mouse, Recombinant (His) calnexin,D11Ertd153e,AI988026,1110069N15Rik,Cnx	Mouse	HEK293 Cells
	Calnexin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.9 kDa and the accession number is P35564.
TMPY-03112	Calnexin Protein, Human, Recombinant (hFc) P90,calnexin,CNX,IP90	Human	HEK293 Cells
	Calnexin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.4 kDa and the accession number is P27824.