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Search Results for " cns disorders "

16

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7626	Budipine	Others	Others
	Budipine 是抗帕金森病剂的一种。
T16849	SB-222200	Neurokinin receptor	GPCR/G Protein; Neuroscience
	SB-222200 是一种选择性口服活性的，具有血脑屏障渗透性的 NK-3 受体拮抗剂，用于中枢神经系统疾病的研究。
T5411	PDE10-IN-1 SEP-0372814	PDE	Metabolism
	PDE10-IN-1 (SEP-0372814) 是一种高效的 PDE10抑制剂。
T10170	5-HT7 agonist 1 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole)是一种5-HT7的选择性激动剂(IC50=222.93 nM)。5-HT7 agonist 1可用于有关中枢神经系统疾病的研究。
T77597	SXC 2023 (S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid	Others	Others
	SXC 2023 ((S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid) 是一种可治疗中枢神经疾病和神经认知障碍的N-乙酰-L-半胱氨酸的前药，可用于治疗谷氨酸能功能障碍和氧化应激起关键作用的精神疾病。
TP2309	NEUROTENSIN TFA (39379-15-2 free base) Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素	Others	Others
	Neurotensin TFA (39379-15-2 free base) 是一种内源性 13 个氨基酸的神经肽，具有显着的阿片类非依赖性镇痛作用。它在大脑中充当神经递质，在肠道中充当激素，也充当神经调节剂。由于它与多种神经递质系统如多巴胺能、血清素能、谷氨酸能、GABA 能和胆碱能系统。它具有作为人体代谢物、有丝分裂原、神经递质和创伤的作用。
T31264	Deanol acetamidobenzoate Deanol p-acetamidobenzoate,Elevan,Diforene,Cervoxan,Deaner
	Deanol acetamidobenzoate is CNS stimulant. It can be caused elevated blood choline levels, can be used in Treatment of Choreiform Movement Disorders.
T61375	5-HT7 agonist 2
	5-HT7 agonist 2 is a highly potent 5-HT7 receptor agonist, exhibiting an IC50 value of 28.7 nM. This compound holds promise for studying and understanding various Central Nervous System (CNS) disorders [1].
T39673	Zagociguat
	Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-central nervous system (CNS) disorders.
T71593	AVN-101 free base
	AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
T61210	R-PSOP
	R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous system (CNS) penetration and is valuable in the study of eating disorders, obesity, pain, and stress-related disorders [1].
T62946	Dopamine D3 receptor antagonist-2
	Dopamine D3 receptor antagonist-2 是一种多巴胺 D3 受体选择性（Ki= 2.16 nM）或多靶点双配体，对中枢神经系统疾病表现出潜在作用。
T38222	N-(α-Linolenoyl) Tyrosine
	Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precurs...
T79804	5-HT2 agonist-1	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT2 agonist-1 (Compound 24) 是一种选择性5-HT2A, 5-HT2B和5-HT2C激动剂，其IC50值分别为10 nM, 8.3 nM和1.6 nM。5-HT2 agonist-1 free base主要用于研究治疗抑郁症、酗酒、吸烟与可卡因依赖、炎症、丛集性头痛、创伤后应激障碍(PTSD)、癫痫以及其他中枢神经系统疾病。
T35930	Ganglioside GM2 Mixture (sodium salt)
	Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2. Gan...
T73359	NYX-2925
	NYX-2925 是一种口服有效的NMDAR 调节剂。NYX-2925 恢复 mPFC 中 GluN2A 和 GluN2B 上活化的Src 和Src 磷酸化位点的水平。NYX-2925 对 CAMKII 没有影响，也没有任何成瘾或镇静/共济失调的副作用。NYX-2925 可用于多种 NMDA 受体介导的中枢神经系统疾病的研究。

化合物

Cat.No: T7626

Target: Others

Cat.No: T16849

Target: Neurokinin receptor

Cat.No: T5411

Synonym: SEP-0372814

Target: PDE

5-HT7 agonist 1

Cat.No: T10170

Synonym: 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole

Target: 5-HT Receptor

Cat.No: T77597

Synonym: (S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid

Target: Others

NEUROTENSIN TFA (39379-15-2 free base)

Cat.No: TP2309

Synonym: Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素

Target: Others

Deanol acetamidobenzoate

Cat.No: T31264

Synonym: Deanol p-acetamidobenzoate,Elevan,Diforene,Cervoxan,Deaner

5-HT7 agonist 2

Cat.No: T61375

Cat.No: T39673

AVN-101 free base

Cat.No: T71593

Cat.No: T61210

Dopamine D3 receptor antagonist-2

Cat.No: T62946

N-(α-Linolenoyl) Tyrosine

Cat.No: T38222

5-HT2 agonist-1

Cat.No: T79804

Target: 5-HT Receptor

Ganglioside GM2 Mixture (sodium salt)

Cat.No: T35930

Cat.No: T73359

Cat. No.	Product Name	Target	Signaling Pathways
T12139	N-(3-Methoxybenzyl)Palmitamide N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5	FAAH	Metabolism; Neuroscience
	N-(3-Methoxybenzyl)Palmitamide 是FAAH 抑制剂，可用于研究疼痛，炎症和中枢神经系统退行性疾病。
TN1048	Cnidilin Knidilin
	Cnidilin (Knidilin) 存在与Angelica dahurica 根中，具有高BBB 通透性，在治疗中枢神经系统疾病方面具有药代动力学潜力。
T3S2105	N-Benzylpalmitamide Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide	Others; FAAH; Autophagy	Autophagy; Metabolism; Neuroscience; Others
	N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱，可以时间依赖性方式抑制脂肪酸酰胺水解酶，有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。

天然产物

N-(3-Methoxybenzyl)Palmitamide

Cat.No: T12139

Synonym: N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5

Target: FAAH

Cat.No: TN1048

Synonym: Knidilin

N-Benzylpalmitamide

Cat.No: T3S2105

Synonym: Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide

Target: Others, FAAH, Autophagy

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