Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10828 |
CK2/PIM1-IN-1
|
Others | Others |
CK2/PIM1-IN-1 is an inhibitor of CK2 and PIM1 (IC50s: 3.787 μM and 4.327 μM). It is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions. | |||
T10827 |
CK2/ERK8-IN-1
TMCB |
Apoptosis; ERK; Casein Kinase; Pim; DYRK | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
CK2/ERK8-IN-1 (TMCB) 是一种酪蛋白激酶 2 (CK2) (Ki 为 0.25 µM) 和 ERK8 (MAPK15, ERK7) 的双重抑制剂,IC50 均为 0.50 μM。CK2/ERK8-IN-1 也与 PIM1,HIPK2 和 DYRK1A 结合,Ki 值分别为 8.65 µM,15.25 µM 和 11.9 µM。 |