Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T32189 |
Iproplatin
JM-9,CHIP,Code name: JM9,JM 9 |
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Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione i | |||
T1960 |
YL-109
|
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
YL-109是一种抗肿瘤剂,可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达,具有抑制乳腺癌细胞生长和侵袭性的能力。 | |||
TP1616L |
Hsp70-derived octapeptide acetate
Hsp70-derived octapeptide acetate(736171-62-3 free base) |
Others | Others |
Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate)(736171-62-3 free base) 是一组含有四肽重复 (TPR) 的蛋白质,已显示与 70 kDa 热休克同源蛋白 (hsc70) 的 C 末端结构域相互作用。在本研究中,含 TPR 的蛋白质,包括 hsc70 相互作用蛋白 (CHIP)、TPR1 和人富含谷氨酰胺的 TPR 含蛋白 (hSGT) 的 C 端,对 DnaJ 和 hsc70 对荧光素酶重折叠的影响进行了调查。 | |||
T31523 | Diptoindonesin G | ||
Diptoindonesin G is an ERß stabilizer that regulates the stability of ERα and ERß by targeting CHIP E3 ubiquitin ligase. Diptoindonesin G could significantly increase the protein stability of ERß, and reduce the protein level of ERα, | |||
T77939 |
WBC100
14-D-Valine-TPL |
c-Myc | Cell Cycle/Checkpoint |
WBC100(14-D-Valine-TPL),一款高效、选择性和具口服活性的c-Myc小分子降解剂,通过针对泛素E3连结酶CHIP介导的26S蛋白酶体途径实现其作用。主要应用于c-Myc过表达肿瘤的研究领域。 | |||
T71925 |
Isonanangenine B
|
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Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells. | |||
T73166 |
FUBP1-IN-2
|
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FUBP1-IN-2 是一种有效的 FUBP1(远上游结合蛋白 1) 抑制剂。在凝胶移位试验中,FUBP1-IN-2 抑制 KH4 FUBP1-FUSE 相互作用。FUBP1-IN-2 在 ChIP 试验中与 FUBP1 结合。FUBP1-IN-2 可降低 c-MycmRNA 和蛋白表达,增加 p21mRNA 和蛋白表达,并消耗细胞内多胺。 | |||
TP1616 |
Hsp70-derived octapeptide
|
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A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus |