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Search Results for " cdkn1a "

Targets Recommended: Histone Methyltransferase Autophagy

4

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7697	BIX-01294	Histone Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。
T1959	BIX-01294 trihydrochloride BIX 01294	Histone Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	BIX-01294 trihydrochloride 是可逆且高度选择性的G9a 和GLP 组蛋白甲基转移酶抑制剂，IC50分别为 1.9 μM 和 0.7 μM。它可诱导坏死性凋亡和自噬，具有抗肿瘤活性。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。
T26259	Tenovin-D3 TenovinD3
	Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.
T73000	SIRT2-IN-11
	SIRT2-IN-11 (AEM1) 是选择性的SIRT2抑制剂，IC50值为 18.5 μM。SIRT2-IN-11 以 p53 依赖的诱导细胞凋亡，激活CDKN1A，PUMA 和NOXA 的表达，并且促进 p53 的乙酰化。SIRT2-IN-11 可用于 p53 相关的癌症研究。

化合物

Cat.No: T7697

Target: Histone Methyltransferase, Autophagy

BIX-01294 trihydrochloride

Cat.No: T1959

Synonym: BIX 01294

Target: Histone Methyltransferase, Autophagy

Cat.No: T26259

Synonym: TenovinD3

Cat.No: T73000

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00578	BCCIP Protein, Human, Recombinant TOK-1,TOK1,BRCA2 and CDKN1A interacting pr...	Human	Baculovirus Insect Cells
	BCCIP Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 36.2 kDa and the accession number is AAH09771.1.
TMPY-04023	BCCIP Protein, Human, Recombinant (His & GST) BRCA2 and CDKN1A interacting protein,TOK-1...	Human	Baculovirus Insect Cells
	BCCIP Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 64 kDa and the accession number is AAH09771.1.
TMPY-04397	PAK-3 Protein, Human, Recombinant (His) PAK3β,hPAK3,bPAK,PAK3beta,MRX30,MRX47,CDKN1A	Human	Baculovirus Insect Cells
	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group...
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc) COMM domain-containing protein 5,COMMD5,Hypertension-related...	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
TMPY-03599	RPRD1B Protein, Human, Recombinant (His) C20orf77,regulation of nuclear pre-mRNA domain containing 1B...	Human	HEK293 Cells
	RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phosphorylated RNAP II at target gene promoters. RNA polymerase II C-terminal domain (CTD) phosphorylation is important for various transcription-related processes. RPRD1B is a transcriptional regulator that enhances expression of CCND1. It also enhances the transcription of a number of...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
TMPH-01282	ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4	Human	E. coli
	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm...

重组蛋白

BCCIP Protein, Human, Recombinant

Cat.No: TMPY-00578

Species: Human

Expression System: Baculovirus Insect Cells

BCCIP Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04023

Species: Human

Expression System: Baculovirus Insect Cells

PAK-3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04397

Species: Human

Expression System: Baculovirus Insect Cells

COMMD5 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03269

Species: Rat

Expression System: E. coli

RPRD1B Protein, Human, Recombinant (His)

Cat.No: TMPY-03599

Species: Human

Expression System: HEK293 Cells

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01282

Species: Human

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

IRF1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

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